نتایج جستجو برای: glutathione peroxidase gshpx

تعداد نتایج: 63181  

Journal: :Circulation 2004
Tetsuya Shiomi Hiroyuki Tsutsui Hidenori Matsusaka Kimiyo Murakami Shunji Hayashidani Masaki Ikeuchi Jing Wen Toru Kubota Hideo Utsumi Akira Takeshita

BACKGROUND Oxidative stress plays an important role in the pathophysiology of heart failure. We determined whether the overexpression of glutathione peroxidase (GSHPx) could attenuate left ventricular (LV) remodeling and failure after myocardial infarction (MI). METHODS AND RESULTS We created MI in 12- to 16-week-old, male GSHPx transgenic mice (TG+MI) and nontransgenic wild-type littermates ...

2002
K. HOLOVSKÁ V. LENÁRTOVÁ P. JAVORSKÝ

Superoxide dismutase (SOD) isoenzymes of the rumen bacterium Streptococcus bovis 4/1 were studied. Native PAGE showed a single band of Mn-SOD, unaffected by 10 mM cyanide or 5 mM hydrogen peroxide under both aerobic and anaerobic growth conditions. When the metals were removed from the growth medium by Chelex 100, the addition of manganese increased enzymatic activity, while addition of iron in...

Raspberry waste, obtained from two cultivars, Meeker (ERM) and Willamette (ERW) was subjected to evaluation antioxidants and antitumour activities as a potential source of phenolics. Some phenolic acids and flavonoids were identified and quantified by HPLC. Antioxidant activity was tested by measuring ability to scavenge DPPH• and •OH by ESR spectroscopy. IC50DPPH• varied from 0.67 for ERM to 0...

Journal: :Indian journal of experimental biology 2005
Madhu C Garg Dharam P Chaudhary Devi D Bansal

Diabetes induced by streptozotocin (50 mg/kg body wt, i.p.) in the rats substantially increased the plasma glucose and malondialdehyde levels along with corresponding decrease in the antioxidants levels. Supplementation of vitamin E (200 mg/kg body wt., ip) for 5 weeks resulted in non-significant decrease in the blood glucose levels but plasma malondialdehyde levels were reduced to below normal...

Journal: :the iranian journal of pharmaceutical research 0
jasna canadanovic-brunet faculty of technology, university of novi sad, serbia jelena vulic faculty of technology, university of novi sad, serbia tatjana cebovic faculty of medicine, university of novi sad, serbia gordana cetkovic faculty of technology, university of novi sad, serbia vladimir canadanovic faculty of medicine, university of novi sad, serbia sonja djilas faculty of technology, university of novi sad, serbia

raspberry waste, obtained from two cultivars, meeker (erm) and willamette (erw) was subjected to evaluation antioxidants and antitumour activities as a potential source of phenolics. some phenolic acids and flavonoids were identified and quantified by hplc. antioxidant activity was tested by measuring ability to scavenge dpph• and •oh by esr spectroscopy. ic50dpph• varied from 0.67 for erm to 0...

2010
Mohamed M Sayed-Ahmed Abdulaziz M Aleisa Salim S Al-Rejaie Abdulaziz A Al-Yahya Othman A Al-Shabanah Mohamed M Hafez Mahmoud N Nagi

Hepatocellular carcinoma accounts for about 80-90% of all liver cancer and is the fourth most common cause of cancer mortality. Although there are many strategies for the treatment of liver cancer, chemoprevention seems to be the best strategy for lowering the incidence of this disease. Therefore, this study has been initiated to investigate whether thymoquinone (TQ), Nigella sativa derived-com...

A. R. Talebian Masoudi, F. Azizi H. Zahedipour

The aim of this study was to provide preliminary quantitative information on selenium and iodine statusof sheep in Markazi province, Iran. Selenium and iodine status of grazing sheep were measured for 57different flocks in 14 regions over one year. The districts were selected to represent major sheep growingareas in the province. Blood samples were collected from 2 to 3-year-old ewes during sum...

Journal: :American journal of physiology. Heart and circulatory physiology 2006
Shouji Matsushima Shintaro Kinugawa Tomomi Ide Hidenori Matsusaka Naoki Inoue Yukihiro Ohta Takashi Yokota Kenji Sunagawa Hiroyuki Tsutsui

Oxidative stress plays an important role in the structural and functional abnormalities of diabetic heart. Glutathione peroxidase (GSHPx) is a critical antioxidant enzyme that removes H(2)O(2) in both the cytosol and mitochondia. We hypothesized that the overexpression of GSHPx gene could attenuate left ventricular (LV) remodeling in diabetes mellitus (DM). We induced DM by injection of strepto...

Journal: :Acta medica Iranica 2017
Hamed Shafaroodi Mehrdad Hashemi Zahra Nadia Sharif Leila Moezi Zeinab Janahmadi Ahmad Reza Dehpour

 Cirrhosis has been related with hyperdynamic circulation, manifesting as increased cardiac output and decreased systemic vascular resistance. In the present study we examined the cirrhosis outcome on apoptosis of rat hearts. We also tried to explore the role of nitric oxide (NO) and oxidative stress in the probable changed apoptosis of cirrhotic hearts. Twenty eight days after ligation of bile...

Journal: :Circulation 2000
T Li P K Singal

BACKGROUND The clinical usefulness of adriamycin is restricted by the development of congestive heart failure. It has been suggested that probucol, a strong antioxidant, completely prevents adriamycin-induced cardiomyopathy without interfering with its antitumor properties. The present study investigated the effects of adriamycin and probucol on myocardial antioxidant enzyme activities and immu...

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