نتایج جستجو برای: glucuronidase
تعداد نتایج: 3231 فیلتر نتایج به سال:
The level of serum beta-glucuronidase increases in various pathological conditions, including liver disorders. The aim of this investigation was to study the changes in liver lysosomal membrane stability during experimentally induced hepatic fibrosis that may result in the elevation of serum beta-glucuronidase. Liver injury was induced by intraperitoneal injections of N-nitrosodimethylamine (ND...
A modification of the method of Fishman, Springer, and Brunetti (1948) for determining serum beta-glucuronidase activity is described. Normal values are presented and some of the factors which might influence the serum enzyme determination have been investigated.
We have investigated the hypothesis that uridine 5 diphosphate (UDP)-glucuronyltransferases (UGTs) and -glucuronidase are jointly involved in a mechanism for the storage and mobilization of iodothyronine metabolites in liver, kidney, heart and brain. Specifically, we predicted UGT activities to decrease and increase respectively, and -glucuronidase activity to increase and decrease respectively...
In view of the relationship shown to exist between the fi-glucuronidase activity of a tissue and its state of growth (Levvy, Kerr & Campbell, 1948), it was considered important to find a specific inhibitor' for this enzyme. It has been suggested (Fishman, 1940), without any direct evidence, that fl-glucuronidase is responsible for the formation of glucuronides in the body. The use of an inhibit...
The objective of the presented study was to examine the influence of Fusarium mycotoxins (zearalenone--ZEN and deoxynivalenol--DON), administered separately and in combination, on the activity of cecal enzymes (β-glucosidase and β-glucuronidase) in gilts which were fed fodder con- taminated with these mycotoxins. The activity of β-glucosidase and β-glucuronidase varied in the range of 0.170-1.2...
Ruta graveolens L. is a source of pharmacologically active molecules such as furocoumarins, furoquinolines and acridone alkaloids. A genetic transformation method using Agrobacterium tumefaciens was developed for this plant species. The conditions for an efficient regeneration of R. graveolens led us to retain hypocotyls among other explants tested. Subsequently, transformation was obtained by ...
Humans express at least two distinct β-glucuronidase enzymes that are involved in disease: exo-acting β-glucuronidase (GUSB), whose deficiency gives rise to mucopolysaccharidosis type VII, and endo-acting heparanase (HPSE), whose overexpression is implicated in inflammation and cancers. The medical importance of these enzymes necessitates reliable methods to assay their activities in tissues. H...
Bacterial b-glucuronidases expressed by the symbiotic intestinal microbiota appear to play important roles in druginduced epithelial cell toxicity in the gastrointestinal (GI) tract. For the anticancer drug CPT-11 (irinotecan) and the nonsteroidal anti-inflammatory drug diclofenac, it has been shown that removal of the glucuronide moieties from drug metabolites by bacterial b-glucuronidases in ...
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