Earlier studies of the A and B allozymes at the G6pd locus show a differential ability of the genotypes to suppress the loss of viability associated with a low activity 6-phosphogluconate dehydrogenase mutation, 6Pgdlo1. This observation indicates a relatively lower activity for the A allozyme genotype, but it is not known if this level of suppression required a large difference in in vivo acti...

People with the variants of glucose-6-phosphate dehydrogenase (GPD) deficiency common in the southern Chinese (Canton, B(-)Chinese, and Hong Kong-Pokfulam) have a moderate shortening of red-cell survival but no anaemia when they are in the steady state. With a cross-transfusion technique, primaquine, nitrofurantoin, and large doses of aspirin were found to aggravate the haemolysis while sulpham...

Recent reports from Sardinia, Greece and Malaya indicate that glucose-6phosphate dehydrogenase (G-6PD) deficiency may constitute an important aetiological factor in the causation of severe neonatal jaundice and kernikterus (Panizon, 1960a, b; Doxiadis, Fessas and Valaes, 1961; Smith and Vella, 1960; Weatherall, 1960). Since this enzyme deficiency is very frequent in certain oriental Jewish comm...

A pilot study was conducted to determine the prevalence and haematological characteristics of the interaction between thalassaemia or/and glucose-6-phosphate dehydrogenase (G6PD) deficiency in patients with sickle-cell disorder (SCD) in Taiz city, Yemen, where the prevalence of sickle-cell trait (HbAS) is 8.2%. Blood samples were collected from 31 SCD patients. Complete blood count and haemoglo...

Mutations in the glucose-6-phosphate dehydrogenase (G6PD) gene result in red blood cells with increased susceptibility to oxidative damage. Significant haemolysis can be caused by primaquine and other 8-aminoquinoline antimalarials used for the radical treatment of Plasmodium vivax malaria. The distribution and phenotypes of mutations causing G6PD deficiency in the male population of migrants a...

OBJECTIVE To evaluate the correlation between glucose-6-phosphate-dehydrogenase (G6PD) deficiency and neonatal jaundice. METHODS Prospective, observational case-control study was conducted on 490 newborns admitted to Hospital de Clínicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation, from March to December 2007. Enzymatic screening of G6PD activity was pe...

The prevalaence of anemia, iron deficiency, thalassemia and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency were examined among 265 hill-tribe school children, 8-14 years of age, from Omkoi District, Chiang Mai Province, Thailand. Anemia was observed in 20 school children, of whom 3 had iron deficiency anemia. The prevalence of G-6-PD deficiency and β-thalassemia trait [codon 17 (A>T), IV...

It is now well established that hyperbilirubinaemia and even kernikterus may occur in the newborn in association with glucose 6 phosphate dehydrogenase (G6PD) deficiency, in the absence of any of the other causes of neonatal jaundice (Panizon, 1960a, b; Doxiadis, Fessas, and Valaes, 1960; Doxiadis, Fessas, Valaes, and Mastrokalos, 1961; Fessas, Doxiadis, and Valaes, 1962; Smith and Vella, 1960;...