The effect of acute extracellular volume expansion with saline on the intrarenal distribution of glomerular filtrate, was studied in dogs utilizing micropuncture techniques in which samples were obtained by both recollection and from new tubules. Recollection was examined in seven dogs during continuous hydropenia and in five dogs during continuous saline diuresis. Recollection was associated w...

conclusions: in this study, kidney transplant recipients with a lower ri and pi and a higher edv at 1week showed better graft function at 6 months after transplantation. results: fourteen patients (15.4%) had impaired graft function after 6 months (gfr less than 60 ml/min/1.73m2). multivariate linear regression analysis showed significant correlation between gfr at 6 months and ri, pi and edv w...

the aim of this study was to determine the effect of aerobic exercises on glomerular filtration rate (gfr) and serum levels of biochemical factors of urea (bun), creatine (cr) and uric acid (uac) in type 2 diabetic men. the sample consisted of 23 type 2 diabetic patients with age range of 45-60 years old who were divided into two groups of experimental (n=13) and control (n=10). experimental gr...

Increased dietary protein and circulating amino acids raise glomerular filtration rate (GFR) and pressure. In diabetes, this glomerular hyperfiltration response is augmented. The purpose of this study was to determine whether glucagon mediates the augmented GFR response to amino acids in diabetes and whether the responses to amino acids and glucagon depend on prostaglandins. Patients with type ...

Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...

Glossary: ADH – antidiuretic hormone AVP – arginine-vasopressin, vasopressin bw – body weight Ccr – changes in glomerular filtration rate (GFR) based on endogenic creatinine clearance Cin – changes in glomerular filtration rate (GFR) based on inulin clearance ERPF – Effective renal plasma flow (ml/min/m2) EPBF – Effective renal blood flow (ml/min/m2) FF – Filtration fraction (%) GFR – Glomerula...

BACKGROUND In critically ill patients with acute kidney injury, estimates of kidney function are used to modify drug dosing, adjust nutritional therapy and provide dialytic support. However, estimating glomerular filtration rate is challenging due to fluctuations in kidney function, creatinine production and fluid balance. We hypothesized that commonly used glomerular filtration rate prediction...

Previous studies have established that in a variety of human glomerulopathies the reduced glomerular filtration rate (GFR) is due to a marked lowering of the ultrafiltration coefficient (Kf). To identify the factors which lower Kf, we measured the filtering surface area per glomerulus, filtration slit frequency, basement membrane thickness, and GFR and its determinants in patients with minimal ...

Micropuncture, clearance, immunofluorescence and light microscopy techniques were used to study kidney structure and single nephron function in rats with autologous immune complex nephritis (AICN), a membranous glomerulonephritis developing over 5 to 20 mo, in the more acute and proliferative glomerular basement membrane (GBM) nephritis and in controls. Both models are known to have clinical co...

Almost one-third of transplanted kidneys come from living donors, who sacrifice approximately 30% of their pre-donation glomerular filtration rate (GFR) after they experience compensatory hypertrophy and hyperfiltration in their remaining kidney. Although hyperfiltration can cause glomerular injury, many studies have suggested that donor nephrectomy itself does not cause long-term loss of GFR a...