context in human beings, uric acid is the poorly soluble circulating end product of the purine nucleotide metabolism. a reduction in the glomerular filtration rate (gfr) contributes to hyperuricemia, which is frequently observed in patients with chronic kidney disease (ckd). evidence acquisition hyperuricemia is defined as a serum uric acid level > 7.0 mg/dl in males and > 6.0 mg/dl in females,...

OBJECTIVES Cystatin C is emerging as an endogenous marker of glomerular filtration rate. This study sought to assess the usefulness of serum cystatin C as a marker of glomerular filtration rate in comparison with serum creatinine and serum creatinine-based glomerular filtration rate estimations in voluntary kidney donors. MATERIALS AND METHODS Serum cystatin C and serum creatinine were estima...

The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for J...

OBJECTIVE Understanding how best to measure renal function in HIV-infected patients is critical because estimated glomerular filtration rate (eGFR) in HIV-infected patients can be affected by ethnicity and body composition. We validated the available eGFR equations and compared them to the plasma Tc-diethylenetriaminepentaacetic acid (Tc-DTPA) clearance in HIV-infected patients. DESIGN Test o...

chronic kidney disease (ckd) is an increasing cause of morbidity and mortality worldwide. prospective data on risk factors for ckd are few. hypertension is one of the risk factors for ckd. in the past serum creatinine concentration was used as marker of kidney function but it proffers a late reflection of reduced glomerular filtration rate(gfr), which limits its ability to detect impaired kidne...

BACKGROUND AND OBJECTIVES The level of glomerular filtration rate at which hemoglobin declines in chronic kidney disease is poorly described in the pediatric population. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This cross-sectional study of North American children with chronic kidney disease examined the association of glomerular filtration rate, determined by the plasma disappearance of...

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