INTRODUCTION The subthalamic nucleus, substantia nigra, and globus pallidus, three nuclei of the human basal ganglia, play an important role in motor, associative, and limbic processing. The network of the basal ganglia is generally characterized by a direct, indirect, and hyperdirect pathway. This study aims to investigate the mesoscopic nature of these connections between the subthalamic nucl...

The effect of unilateral intrapallidal cannabinoid receptor stimulation on rotational behavior in rats was explored. The potent cannabinoid agonist CP55,940 (5 microg/0.5 microl) induced ipsilateral turning when microinjected unilaterally into the globus pallidus. The D2 dopamine agonist quinpirole reversed this ipsilateral rotation but failed to affect motor behavior on its own. Finally, the D...

Citation: Pan Y, Wang L, Zhang Y, Zhang C, Qiu X, Tan Y, Zhou H, Sun B and Li D (2018) Deep Brain Stimulation of the Internal Globus Pallidus Improves Response Initiation and Proactive Inhibition in Patients With Parkinson’s Disease. Front. Psychol. 9:351. doi: 10.3389/fpsyg.2018.00351 Deep Brain Stimulation of the Internal Globus Pallidus Improves Response Initiation and Proactive Inhibition i...

Deep brain stimulation (DBS) surgery has become increasingly utilized in the treatment of advanced Parkinson's disease. Over the past decade, a number of studies have demonstrated that DBS is superior to best medical management in appropriately selected patients. The primary targets for DBS in Parkinson's disease include the subthalamic nucleus and the internal segment of the globus pallidus, b...

Bilateral and symmetric globus-pallidus hyperintensities are observed on T1-weighted MRI in most of the patients with chronic liver failure, due to manganese accumulation. We report a 53-year-old man, with rapid onset parkinsonism-dementia complex associated with accumulation of manganese in the brain, secondary to liver failure. A brain MRI was performed and a high signal on T1-weighted images...

The cortex and basal ganglia are the major structures of the adult brain derived from the embryonic telencephalon. Two morphologically distinct regions of the basal ganglia are evident within the mature ventral telencephalon, the globus pallidus medially, and the striatum, which is positioned between the globus pallidus and the cortex. Deletion of the Sonic Hedgehog gene in mice indicates that ...

Of 60 patients with acute carbon monoxide (CO) intoxication caused by accidental or intentional inhalation of natural gas, smoke inhalation, or inhalation of automobile exhaust, 23 had characteristic computed tomographic findings. The most common finding, seen in 21 patients, was symmetric and diffuse low density in the cerebral white matter, which was more advanced in the centrum semiovale and...