The goal of the Globe project is to design and build a middleware platform that facilitates the development of large-scale distributed applications, such as those found on the Internet. To demonstrate the feasibility of our design and to test our ideas, we are currently building a new Internet application: The Globe Distribution Network. The Globe Distribution Network, or GDN, is an application...

Canadian Family Physician focuses on a special theme in this issue: poverty and human development. This month, we share this theme with more than 200 journals around the world. Two College members have seen our world as a spinning blue, green, and white orb. As astronauts, Dr Robert Thirsk and Dr Dave Williams have experienced this particular view of our home planet. Although that type of world...

Introduction: Pharmacovigilance (PV) plays a consequential role in the drug regulatory system and is constantly evolving multifaceted field. In process of carrying out its effective management, PV does undergo lot challenges on global pitch. well developed western globe (United States, United Kingdom, Germany) while east (e.g.: India) still stage.
 Methods: Major discrepancies include diff...

The concept of lamellar keratoplasty (LK) is not new. However, newer forms of lamellar keratoplasty techniques have emerged in the last decade or so revolving around the concept of targeted replacement of diseased corneal layers. These include anterior lamellar keratoplasty (ALK) techniques that aim to selectively replace diseased corneal stroma and endothelial keratoplasty techniques aiming to...

Ex vivo lung perfusion (EVLP) has emerged as a new technique for assessing and potentially reconditioning human donor lungs previously unacceptable for clinical transplantation with the potential to dramatically push the limits of organ acceptability. With the recent introduction of portable EVLP, a new era in lung preservation may be upon us with the opportunity to also limit organ ischaemic t...

Vitamins and related compounds, such as provitamins, biopigments and antioxidants, belong to those few chemicals that appeal in a positive way to most people. These terms sound synonymous to vitality, good health and mental strenght, even to the layman. Everyone of us needs his/her daily intake of (pro)vitamins and antioxidants, normally provided by a balanced and varied diet. However, current ...

PURPOSE To evaluate long-term outcomes of proton beam radiotherapy in the treatment of choroidal melanoma of the intermediate zone of the fundus. DESIGN Retrospective interventional single-center study. METHODS The study was a retrospective analysis with long-term follow-up of 62 patients with a minimum tumor-to-disc and tumor-to-fovea distance of 2 mm of choroidal melanoma in the intermedi...