Resistance to oseltamivir, the most widely used influenza antiviral drug, spread to fixation in seasonal influenza A(H1N1) between 2006 and 2009. This sudden rise in resistance seemed puzzling given the low overall level of the oseltamivir usage and the lack of a correlation between local rates of resistance and oseltamivir usage. We used a stochastic simulation model and deterministic approxim...

Measuring the impact of drug resistance is an important step in understanding the scope of the problem and formulating policies to limit the emergence and spread of resistant organisms. Studies have focused on measuring the increased costs, morbidity, and mortality in patients with infections due to resistant versus susceptible organisms. These have generally found that resistance worsens outco...

For more on breastfeeding and the Affordable Care Act see http://www.cdc.gov/ breastfeeding/pdf/BFGuide-508.PDF Breastmilk makes the world healthier, smarter, and more equal: these are the conclusions of a new Lancet Series on breastfeeding. The deaths of 823 000 children and 20 000 mothers each year could be averted through universal breastfe eding, along with economic savings of US$300 billio...

In the 20th century, political leaders and governments throughout the world supported drug prohibition and constructed a global drug prohibition system. They did so because of the influence of the USA and its allies and the UN. This article suggests they also did so because drug prohibition, drug demonisation and anti-drug campaigns were very useful*/especially to politicians, the police, the m...

BACKGROUND Network science is already making an impact on the study of complex systems and offers a promising variety of tools to understand their formation and evolution in many disparate fields from technological networks to biological systems. Even though new high-throughput technologies have rapidly been generating large amounts of genomic data, drug design has not followed the same develop...