نتایج جستجو برای: gist tumor
تعداد نتایج: 430446 فیلتر نتایج به سال:
Objectives: Gastrointestinal stromal tumor (GIST) is a that rarely found and characterized by positive KIT (CD117) DOG1 results. Multiple myeloma (MM) malignant proliferation of uncontrolled plasma cells in the bone marrow which produces abnormal proteins or urine. The coexistence GIST other solid cancers gastrointestinal tract urinary have been widely reported, but with hematologic malignancie...
BACKGROUND Although GIST generally occurs in the digestive tract, such as the stomach, and small and small intestine primarily, Omental GIST tumours are very rare. CASE PRESENTATION A 63-year-old male patient, who recognized an abdominal tumor 1 year before admission, had a slight expansion of the tumor, reduction of the body and malaise, was consulted to our hospital. Abdominal CT and MRI re...
The activity of the receptor tyrosine kinase KIT is crucial for gastrointestinal stromal tumor (GIST) growth and survival. Imatinib and sunitinib are very effective in advanced GIST, but have no curative potential. The observation that heat shock protein 90 (HSP90) inhibition results in KIT degradation prompted us to assess the efficacy of the HSP90 inhibitor retaspimycin hydrochloride (IPI-504...
Gastrointestinal stromal tumors (GISTs) may be defined as morphologically spindle cell, epithelioid, or occasionally pleomorphic mesenchymal tumours of the gastrointestinal tract that usually express the KIT protein and harbour mutation of a gene that encodes for a type III receptor tyrosine kinase (either KIT or PDGFRA). In Caucasian populations their annual incidence is 10 to 15 cases per mil...
Gastrointestinal stromal tumor (GIST) is a rare form of mesenchymal tumor of the gastrointestinal tract, accounting for 1% of malignant neoplasms [1]. Most gastrointestinal mesenchymal tumors are GISTs, originating from interstitial cells of Cajal or precursors of these cells. Although several reports regarding GIST have incrementally advanced our understanding of this condition in recent years...
Metastasis of gastrointestinal stromal tumor (GIST) into the central nervous system is extremely rare. We report a patient with synchronous GIST and brain metastasis. At disease onset, there was left hemiplegia and ptosis of the right eyelids. Resection cytology of the brain tumor was reported as metastasis of GIST. After positron emission tomography examination, another tumor in the small bowe...
Prognostic markers are urgently needed to optimize the postoperative treatment strategies for gastrointestinal stromal tumors (GIST). GIST of the small intestine (I-GIST) show more aggressive behavior than those of the stomach (S-GIST), and the molecular background of the malignancy in I-GIST may include potential prognostic biomarkers. We conducted integrated proteomic and transcriptomic analy...
BACKGROUND Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. The majority of GISTs is located in the stomach. Only 3-5% of GISTs are located in the duodenum associated with an increased risk of gastrointestinal bleeding as primary manifestation. With response rates of up to 90%, but complications like bleeding due to tumor necrosis in 3%, ima...
Collision tumors involving GIST are very rare. Herein, we report a collision tumor consisting of gastric gastrointestinal stromal tumor (GIST) and pancreatic ductal adenocarcinoma. The patient was a 76-year-old Chinese male, presenting with abdominal distension, haematemesis and melena. Both the CT scan images and the gross appearance demonstrated special features indicating the possibility of ...
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