BACKGROUND Frailty can lead towards serious adverse consequences, such as disability. With regard to prevention valid screening instruments are needed to identify frail older people. The aim was to evaluate and compare the psychometric properties of three screening instruments: the Groningen Frailty Indicator (GFI), the Tilburg Frailty Indicator (TFI) and the Sherbrooke Postal Questionnaire (SP...

R. A. Fisher, the father of modern statistics, proposed the idea of fiducial inference during the first half of the 20th century. While his proposal led to interesting methods for quantifying uncertainty, other prominent statisticians of the time did not accept Fisher’s approach as it became apparent that some of Fisher’s bold claims about the properties of fiducial distribution did not hold up...

The genetic and phenotypic associations between performance and feed intake traits of finished gilts (GFI), along with their subsequent reproductive performance and feed intake during lactation (LFI), were estimated using data collected from two maternal lines recorded under the same management system. Ad-libitum feed intake was heritable (h: 0.33±0.08) when recorded in post-finisher gilts or d...

The mechanisms underlying granulocyte-colony stimulating factor (G-CSF)-induced mobilization of granulocytic lineage cells from the bone marrow to the peripheral blood remain elusive. We provide evidence that the transcriptional repressor growth factor independence-1 (Gfi-1) is involved in G-CSF-induced mobilization of granulocytic lineage cells from the bone marrow to the peripheral blood. We ...

We have previously shown that hedamycin, a GC-rich DNA-binding antitumor agent, downregulates survivin transcription (Wu et al. (2005) Molecular mechanism of inhibition of survivin transcription by the GC-rich sequence selective DNA-binding antitumor agent, hedamycin: evidence of survivin downregulation associated with drug sensitivity. J. Biol. Chem., 280, 9745-9751). Here, we report that trea...

OBJECTIVES/HYPOTHESIS Nonparalytic glottic incompetence (GI) encompasses a variety of laryngeal pathologies, and vocal outcome data for this group is limited. We report a subgroup analysis of validated, subjective, and perceptual voice outcome measures: voice-related quality of life (VRQOL), Glottal Function Index (GFI), and GRBAS (grade, roughness, breathiness, asthenia, and strain), after typ...

Gfi-1 was first cloned from rats (and subsequently from mice, chickens, and humans) and was found to be a 55-kDa protein that bound to DNA in a sequence-specific manner to act as a transcriptional repressor and proto-oncogene. Using PCR, a Gfi-1 homologous cDNA (mdGfi-1) was cloned from the house fly, Musca domestica. Comparison of the mdGfi-1-deduced amino acid sequence with those of vertebrat...

Goaf Frictional Ignition (GFI) poses a serious threat to the safety of underground coal mines, and has caused many underground fires and catastrophic explosions. This paper examined occurrences of GFI incidents and the underlying mechanisms of ignition source and environment. Most of these incidents were attributed to rock on rock frictional ignition. The eventuation of frictional ignition reli...