Choriocarcinoma is part of a rare spectrum of placental abnormalities known as gestational trophoblastic disease (GTD). It is the most invasive form of GTD, with a mortality rate approaching 100% if left untreated. It spreads predominantly hematogenously to multiple target sites, most commonly the lungs. Due to its hypervascular nature, it is often complicated by bleeding. We describe a case of...

PURPOSE The objective of this study was to assess the predictive role of the neutrophil/lymphocyte ratio (NLR) for invasion of gestational trophoblastic disease (GTD). MATERIALS AND METHODS A retrospective analysis was conducted on 127 women who were managed at our clinic for GTD. Of all patients, 8 showed invasion according to histological examination. The clinical parameters of patients wit...

Background: Gestational Trophoblastic Disease (GTD) is a heterogeneous group of diseases that includes partial and complete hydatidiform mole, invasive choriocarcinoma placental site trophoblastic tumour. The study aimed to determine the clinical presentation management options outcome GTD in patients admitted tertiary hospital Bangladesh.
 Materials methods: This prospective observational...

Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds leptin. Leptin is an obesity-associated peptide hormone overexpressed in gestational trophoblastic disease (GTD). GTD encompasses several placental abnormalities that range from benign to malignant. Among GTD, molar placentas are characterized by excess proliferation, whereas gestational trophoblastic neopl...

Gestational trophoblastic disease (GTD) represents a spectrum of lesions characterised by an abnormal proliferation of trophoblast, including complete hydatidiform mole, partial hydatidiform mole, invasive hydatidiform mole, choriocarcinoma, placental site trophoblastic tumour, epithelioid trophoblastic tumour, placental site nodule and plaque, and exaggerated placental site reaction. Complete ...

Abbreviations: HCG: Human Chorionic Gonadotropin; Β-hCG: Β-Human Chorionic Gonadotropin; DVT: Deep Vein Thrombosis; TMP-SMX: Trimethoprim and Sulfamethoxazole; EBV: Epstein Barr Virus; ALT: Alanine Aminotransferase; AST: Aspartate Aminotransferase; ALP: Alkaline Phosphatase, PT: Prothrombin Time; CBC: Complete Blood Cell; AFLP: Acute Fatty Liver of Pregnancy; DKA: Diabetic Ketoacidosis; GTD: Ge...

BACKGROUND AND INTRODUCTION Gestational trophoblastic disease (GTD) is a disease of the proliferative trophoblastic allograft. Diagnosis and treatment of GTN in low resource-income countries is challenging due to numerous factors. The objective of this study was to review outcomes of gestational trophoblastic neoplasia in women of low socioeconomic status with limited resources and social suppo...

http://dx.doi.org/10.1016/j.ebiom.2016.01.013 2352-3964/Crown Copyright © 2016 Published by Elsevie Gestational trophoblastic diseases (GTD) are a group of disorders that originate from the trophoblast, which is the outer layer of the blastocyst that normally gives rise to the placenta and is the first tissue to differentiate from the developing embryos after implantation. The human chorionic g...