OBJECTIVE To compare the effects of hospital cleaning agents and germicides on the survival of epidemic Clostridium difficile strains. METHODS We compared the activity of and effects of exposure to 5 cleaning agents and/or germicides (3 containing chlorine, 1 containing only detergent, and 1 containing hydrogen peroxide) on vegetative and spore forms of epidemic and non-epidemic C. difficile ...

Cetyl pyridinium chloride is a cationic detergent which is soluble in water, chloroform, alcohol, and acetone. Aqueous solutions are clear, colorless, and odorless. The agent has a depressant action upon surface tension. This property enhances the value of the germicide because irregular surfaces are uniformly wetted. The germicidal properties of cetyl pyridinium chloride were first studied in ...

Ever since Pasteur showed that spoilage was due to microorganisms, food preservation has been primarily concerned with finding methods for reducing the microbial populations. In order to extend the edible life of shellfish, its bacterial contamination must be reduced to levels sufficiently low to prevent their metabolic products from subverting these foods before they are consumed. Shellfish fo...

This case study examines the effect that Reynolds number of air flow has on population oflive pathogenic microorganisms during process sterilization using ultraviolet germicidalirradiation (UVGI) lamp in a closed air-duct. With this aim, first discussion is mathematicalmodel which regulates changes to terms percentage populationfor following live microorganisms: Escherichia coli, Mycobacterium ...

In a series of publications which have appeared during the last five years (1-8), the activity of certain organic compounds, particularly propylene and triethylene glycols, in killing air-borne bacteria and viruses has been described. The types of microorganisms found to be susceptible and some effects on this killing action of changes in the temperature, relative humidity, and concentration of...

The aim of this study was evaluation an organic germicide (Aquagerm) histological affects on Rainbow trout (Oncorhynchus mykiss) vital tissues. This new disinfectant is an aquatic antiseptic and mixed-oxidant disinfectant which is produced for the first time in Iran. This new product mechanism is based on oxidant properties of pro-sulphate which attack crucial structures of pathogens. In this s...

Chlorhexidine gluconate is a bisguanide germicide currently available with 70% isopropanol (Hibistat, Hibitane) or a detergent (Hibiclens, Hibiscrub) for preoperative skin preparation. As these solvents are toxic to the cornea, we investigated the safety and efficacy of aqueous chlorhexidine solutions for ophthalmic use. Chlorhexidine in Tris-glycine buffer was evaluated for retardation of epit...

OBJECTIVES This study was conducted to review the validity of the need for the application of the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) to household chemical products in Korea. The study also aimed to assess the severity of health and environmental hazards of household chemical products using the GHS. METHODS 135 products were classified as 'cleaning age...

BACKGROUND The spread of antibiotic-resistant pathogens represents an increasing threat in healthcare facilities. Concern has been expressed that the use of surface disinfectants and antiseptics may select for antibiotic-resistant pathogens. OBJECTIVE To review the scientific literature on whether there is a link between use of germicides (ie, disinfectants and antiseptics) and bacterial resi...

izontal surfaces in the rooms of patients with C. difficile infection. It would be obtuse to assume that in vitro experiments precisely simulate in vivo conditions. Similarly, relying solely on an antimicrobial agent's minimum inhibitory concentration to predict its clinical efficacy against a particular infecting pathogen is ill-advised. Thus, it is standard practice to employ in vitro models ...