BACKGROUND Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulti...

conclusions based on evidence, dentists and dental health care professionals should consider periodontal disease as a risk factor for the development of neoplasms in the oral cavity. it also seems a good idea to provide periodontal therapy for patients with cancer to achieve ideal therapeutic results. results cancer of the oral cavity and periodontal disease are related from different aspects. ...

BACKGROUND Teratomas are a spectrum of neoplasms that can undergo malignant transformation. In the World Health Organization (WHO) classification of tumors, this entity was classified as «teratoma with somatic-type malignancy», was defined as a malignant neoplasm of non-germinal phenotype that originates in a teratoma. MATERIALS AND METHODS We present a serie of nine cases of testicular terat...

Germ cell cancer is the most common malignancy in men aged 15–35 years; 5% of the malignant germ cell tumors are of extragonadal origin [1]. An extragonadal germ cell tumor (EGGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads. This specific clinical entity was first described in the 19th century [2, 3]....

Objective(s):Mesenchymal stem cells (MSCs) derived from Wharton’s jelly (WJ-MSCs) are now much more appealing for cell-based infertility therapy. Hence, WJ-MSCs differentiation toward germ layer cells for cell therapy purposes is currently under intensive study. Materials and Methods: MSCs were isolated from human Wharton’s jelly and treated with BMP4, retinoic acid (RA) or co-cultured on huma...

objective(s): sertoli cells support in vivo germ cell production; but, its exact mechanism has not been well understood. the present study was designed to analyze the effect of sertoli cells in differentiation of mouse embryonic stem cells (mescs) to germ cells.   materials and methods: a fusion construct composed of a stra8 gene promoter and the coding region of enhanced green fluorescence pro...

germline and somatic stem cells are distinct types of stem cells that are dedicated to reproduction and somatic tissue regeneration, respectively. germline stem cells (gscs), which can self-renew and generate gametes, are unique stem cells in that they are solely dedicated to transmit genetic information from generation to generation. we developed a strategy for the establishment of germline st...

background:gossypol is a yellow toxic pigment from the cottonseed that can cause acute or chronic toxicity in humans and animals by affecting the testicular tissues. nowadays cottonseed is used as food supplement for ruminants specially the sheep. in this study, two different stem cell lines of testicular tissue including gc1-spg (mouse testis) and sftf-pi43 (sheep testis) cells were used to ev...

malignant germ-cell tumors (mgct) are rare tumors of childhood accounting for less than 3% of pediatric malignancies. endodermal sinus tumor (est) forms the most common histologic subtype of mgct. the vagina is an extremely rare site for gcts. an 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. she was pale and a mass was palpable ...

malignant mixed germ cell tumors,though rare overall, are the most common type of malignant ovarian neoplasms in young and adolescent girls. these tumors are rapidly growing and can metastasize. we report a case of 13-yr-old girl who presented at shkm gmc, nalhar, mewat, haryana, india in december 2013 with huge abdominal lump of a malignant mixed germ cell tumor comprising both immature terato...