The Paternò-Büchi (PB) reaction of geraniol derivatives 1, which contain allylic alcohol functionality and unfunctionalized double bonds, with benzophenone was investigated to see the effect of the hydroxyl group on the regioselectivity of the oxetane formation, i.e., 2/3. At low concentration of geraniol (1a), oxetanes 2a and 3a were formed in a ratio of 2a/3a = ca. 50/50. The oxetane 2a is de...

Studies on the biosynthesis of oil compounds in Perilla will help in understanding regulatory systems of secondary metabolites and in elucidating reaction mechanisms for natural product synthesis. In this study, two types of alcohol dehydrogenases, an aldo-keto reductase (AKR) and a geraniol dehydrogenase (GeDH), which are thought to participate in the biosynthesis of perilla essential oil comp...

The present study aimed to chemically characterize 31 accessions and seven cultivars of basil. The percentage composition of the essential oils of the accessions and cultivars was based on the 14 most abundant constituents: 1,8-cineole, linalool, methyl chavicol, neral, nerol, geraniol, geranial, methyl cinnamate, β-bourbonene, methyl eugenol, α-trans-bergamotene, germacrene-D, epi-α-cadinol, a...

The present study deals with the identification, isolation and in silico characterization of gene encoding geraniol dehydrogenase from Ocimum americanum. Mature leaves of plants have a higher degree of secondary metabolites that hampers the nucleic acid isolation, PCR amplification and other downstream reactions. The DNA isolation from mature leaves of O. americanum is described here which invo...

Volatile oils from single plants of Thymus serpylloides ssp. gadorensis were collected from Southeastern Spain and studied to check for chemical variability using gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Many of the samples showed a phenolic chemotype, while another important group had significant levels of linalool. Geraniol, myrcene, caryophyllene oxide, terpi...

Essential oils are a mixture of volatile and natural substances, identified and characterized by the strong odor, produced by aromatic plants as secondary metabolites. Their metabolites have a wide range of applications and have been commercially important to the pharmaceutical, food and cosmetic industries. One of the plants essential oil Geraniol, a monoterpene alcohol has the verity of pharm...

Surface glandular trichomes distributed throughout the aerial parts of sweet basil (Ocimum basilicum) produce and store monoterpene, sesquiterpene, and phenylpropene volatiles. Three distinct basil chemotypes were used to examine the molecular mechanisms underlying the divergence in their monoterpene and sesquiterpene content. The relative levels of specific terpenes in the glandular trichomes ...

BACKGROUND Monoterpenes are important contributors to grape and wine aroma. Moreover, certain monoterpenes have been shown to display health benefits with antimicrobial, anti-inflammatory, anticancer or hypotensive properties amongst others. The aim of this study was to construct self-aromatizing wine yeasts to overproduce de novo these plant metabolites in wines. RESULTS Expression of the Oc...

We appreciate the comments by Marcuzzi. Marcuzzi et al. (1) and we (2) showed that the pamidronate stimulates the secretion of proinflammatory cytokines in mouse model and in human respectively. Although we measured the acute phase response caused by intermittent large dose aminobisphosphate whereas Marcuzzi emphasized on the inflammatory effect of aminobisphosphate and its reversal by geraniol...

A novel iontophoretic system utilizing ion-exchange membranes is effective for selective transdermal delivery of ionized drugs. In the present study, we examined in vivo availability and safety of ion-exchange iontophoresis in the transdermal delivery of anionic diclofenac, a well known anti-inflammatory medication, to rat dorsal skin. While iontophoresis increased the plasma concentration of d...