in this research,qsar study has been carried out on quinolizidinyl derivatives as potent inhibitors of acetyl and butyrylcholin esterase in alzheimer’s disease. despite significant research efforts in both industry and academia, there are currently no diseases modifying therapies available to treat this illness. significant evidence suggests that the pathology of ad is linked to generation of β...

Background: The motions of body and tumor in some regions such as chest during radiotherapy treatments are one of the major concerns protecting normal tissues against high doses. By using real-time radiotherapy technique, it is possible to increase the accuracy of delivered dose to the tumor region by means of tracing markers on the body of patients.Objective: This study evaluates the accuracy ...

one of the main aims of water resource planners and managers is to estimate and predict the parameters of groundwater quality so that they can make managerial decisions. in this regard, there have many models developed, proposing better management in order to maintain water quality. most of these models require input parameters that are either hardly available or time-consuming and expensive to...

Background and Objectives: Rheological characteristics of dough are important for achieving useful information about raw-material quality, dough behavior during mechanical handling, and textural characteristics of products. Our purpose in the present research is to apply soft computation tools for predicting the rheological properties of dough out of simple measurable factors. Materials and Me...

This paper deals with modeling and optimization of the roll-bonding process of Ti/Cu/Ti composite for determination of the best roll-bonding parameters leading to the maximum Ti/Cu bond strength by combination of neural network and genetic algorithm. An artificial neural network (ANN) program has been proposed to determine the effect of practical parameters, i.e., rolling temperature, reduction...

bedload transport is an essential component of river dynamics and estimation of its rate is important to many aspects of river management. in this study, measured bedload by helley- smith sampler was used to estimate the bedload transport of kurau river in malaysia. an artificial neural network, genetic programming and a combination of genetic programming and a neural network were used to estim...

The purpose of this study is to optimize the stock price forecasting model with meta-innovation method in pharmaceutical companies.In this research, stock portfolio optimization has been done in two separate phases.The first phase is related to forecasting stock futures based on past stock information, which is forecasting the stock price using artificial neural network.The neural network used ...

this paper presents a hybrid approach to developing a short-term traffic flow prediction model. in thisapproach a primary model is synthesized based on neural networks and then the model structure is optimized throughgenetic algorithm. the proposed approach is applied to a rural highway, ghazvin-rasht road in iran. the obtainedresults are acceptable and indicate that the proposed approach can i...