The emergence and spread of resistance in Enterobacteriaceae are complicating the treatment of serious nosocomial infections and threatening to create species resistant to all currently available agents. Approximately 20% of Klebsiella pneumoniae infections and 31% of Enterobacter spp infections in intensive care units in the United States now involve strains not susceptible to third-generation...

Twelve years ago an annotation was published in Archives of Disease in Childhood regarding the antibiotic treatment of suspected neonatal meningitis. The authors recommended the use of cephalosporins rather than chloramphenicol and advocated intraventricular aminoglycoside treatment in selected cases. They noted the absence of clinical trials with third generation cephalosporins that showed an ...

BACKGROUND AND OBJECTIVE 13-Lactams are the most commonly used antibiotics but they can cause hypersensitivity reactions. We sought to estimate cross-reactivity and tolerability of cephalosporins in patients with cell-mediated allergy to penicillins. METHODS We studied 97 patients with a clinical history of nonimmediate reactions to a penicillin and a positive patch test result to at least 1 ...

therapy in resistant enteric fever, various drugs singly, or in combination, such as cotrimoxazole and cephalosporins, or cephalexin and gentamicin, third generation cephalosporins and newer quinolones have been tried with varying results. This communication describes our observations on the clinical profile of children with enteric fever due to MDRST infection and, compare different drug regim...

Article history: Received on: 04/03/2013 Revised on: 28/03/2013 Accepted on: 15/04/2013 Available online: 27/04/2013 The purpose of this study is to rationalize the use of cephalosporins in various common bacterial infections like infections of upper and lower respiratory tract, urinary tract, gastrointestinal tract and of soft tissues in pediatrics (age range: neonate – 10 yrs). A retrospectiv...

Fanling Integrated Treatment Centre, 6/F, Fanling Health Centre, 2 Pik Fung Road, Fanling, New Territories Gonococcal infection is one of the commonly encountered sexually transmitted diseases. The emergence of antibiotic resistance has remained a challenge for a few decades. The third generation cephalosporins are now the first-line therapy in many regions, however, the reduction of the suscep...

A 10% cross-reactivity rate is commonly cited between penicillins and cephalosporins. However, this figure originated from studies in the 1960s and 1970s which included first-generation cephalosporins with similar side-chains to penicillins. Cephalosporins were frequently contaminated by trace amount of penicillins at that time. The side-chain hypothesis for beta-lactam hypersensitivity is supp...

The incidence of Clostridium difficile-associated diarrhea (CDAD) has increased dramatically in hospitals worldwide during the past 2 decades. In Western Australia, this increase was most obvious during the 1980s, when there was also an increase in the use of third-generation cephalosporin antibiotics. A study of the epidemiology of CDAD and the use of third-generation cephalosporins during 199...