Tenofovir disoproxil fumarate (TDF), the bisphosphonate ester prodrug of tenofovir (TFV), has poor bioavailability due to intestinal degradation and efflux transport. Reformulation using U.S. Food and Drug Administration-approved esterase and efflux inhibitors to increase oral bioavailability could provide lower dose alternatives and reduce costs for patients with HIV in resource-limited settin...

With the on-going pandemic, vaccine developing methods have gained attention of scientific community, specially towards production, downstream and transport aspects, making it clear that new with less complex production are needed, especially for countries. In this work we review current used platforms, distribution aspects along challenges faced by each approaches. Some studies also been carri...

According to risk systems theory and the characteristics of the chemical industry, an index system was established for risk assessment of enterprises in chemical industrial parks (CIPs) based on the inherent risk of the source, effectiveness of the prevention and control mechanism, and vulnerability of the receptor. A comprehensive risk assessment method based on catastrophe theory was then pro...

Calendula officinalis Linn. commonly known as marigold has long history of usage by the folklore system. It has a high economic value as herbal medicine and is widely used in cosmetics, perfumes, dyes, pharmaceutical preparations and food products for centuries. The plant has been approved for food use and appears in the food and drug administration (FDA) list of generally recognized as safe (G...

The green model microalga Chlamydomonas reinhardtii recently emerged as a sustainable production chassis for the efficient biosynthesis of recombinant proteins and high-value metabolites. Its capacity scalable, rapid light-driven growth in minimal salt solutions, its simplicity genetic manipulation “Generally Recognized As Safe” (GRAS) status are key features application industrial biotechnolog...

Nanocellulose (NC) has become a topic of increasing interest in recent years due to its special characteristics (including viscous properties and large specific surface area) potential wide applications. Currently NC been widely used number fields, including textile, pharmacy, cosmetics, medicine packaging. However, so far there are limited studies on the behavior along gastrointestinal tract (...

Abstract Biodegradable PLA which is produced by polymerization of lactic acid derived from the starch plants a good candidate for replacing current petroleum-based polymers such as polystyrene (PS) or Polypropylene (PP) in food packaging application. These do contribute to large-scale environmental pollution it non-degradable polymer. Being classified Generally Recognized As Safe (GRAS) contact...

Abstract Today, a few hundred mycotoxins have been identified and the number is rising. Mycotoxin detoxification of food feed has technically uphill task for industry. In twenty-first century, public demand healthy with minimum use chemicals preservatives. Among all fungal inhibition mycotoxin methods so far developed food, biopreservation biodetoxification found safe reliable. Nowadays, lactic...