نتایج جستجو برای: gene inhibitors
تعداد نتایج: 1290958 فیلتر نتایج به سال:
Abstract Differentially Expressed Genes (DEGs) are treated as candidate biomarkers, and a small set of DEGs might be identified biomarkers using either biological knowledge or data-driven approaches like machine learning statistical analysis. In this study, we used combination the algorithm tests to identify top 300 genes that differentially expressed in ASD compared Typically Developed (TD). I...
Frontline acute myeloid leukemia (AML) treatment is determined by a combination of patient and genetic factors. This includes fitness (i.e., comorbidities that increase the risk treatment-related mortality) characteristics, including cytogenetic events gene mutations. In older unfit patients, standard care typically venetoclax (VEN) combined with hypomethylating agents (HMA). Recently, several ...
Background: Influenza viruses are one of the most important etiological agents of res-piratory disease in humans and cause epidemics and pandemics with substantial mor-bidity and mortality worldwide. Vaccination and antiviral treatments are the sole and essential way for the prevention and control of influenza infection. During an influenza epidemic before the production of effective vaccine, a...
Inhibitors from lignocellulosic biomass have become the bottleneck of biorefinery development. Gluconobacter oxydans DSM2003 showed a high performance inhibitors degradation, which had short lag time in non-detoxified corn stover hydrolysate and could convert 90% aldehyde to weaker toxic acids. In this study, an dehydrogenase gene W826-RS0111485, plays important function conversion DSM2003, was...
Background and aim: Cytokines are a large family of protein messengers. These proteins induce various cellular responses. Janus kinases (JAKs) are mediators of cytokine, activated JAKs phosphorylate signal transducers, and activators of transcription (STAT) proteins that regulate cell differentiation, proliferation, and apoptosis. Aberrant JAK/STAT signaling is involved in the oncogenesis of se...
Background and aim: Aberrant activation of diverse intracellular signaling pathways involved in differentiation, cell growth, apoptosis. These pathways include known oncogenic pathways such as Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway. The JAK/STAT signaling pathway plays an important role in many cellular functions. This pathway can be activated by variou...
staphylococcus aureus causes a wide variety of infections worldwide. methicillin-resistant s. aureus is one of most common causes of nosocomial and community acquired infections. the fluoroquinolones are an important class of antibiotics that used to treat infections caused by s. aureus. today, a significant increase in the rate of ciprofloxacin resistance in methicillin-resistant s. aureus str...
In this issue of Cancer Cell, Yang et al. describe a causal relationship between gene body methylation and gene expression and a role for genic methylation in response to clinical DNA methylation inhibitors, which suggests that the mechanism of action of these inhibitors includes gene body hypomethylation-induced downregulation of cancer-associated genes.
Objective(s): To investigate the role of the microRNA-125a (miR-125a) and BAK1 in intervertebral disc degeneration (IDD). Materials and Methods: Degenerative lumbar nucleus pulposus (NP) tissues were obtained from 193 patients who underwent resection, and normal controls consisted of normal NP tissues from 32 patients with traumatic lumbar fracture in our hospital. All patients were graded acco...
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