Abstract Background The clinical endoscopic phenotypes of gastroesophageal reflux disease (GERD) are classified as Barrett's esophagus (BE), erosive esophagitis (EE) and non-erosive (NERD). NERD is subclassified abnormal acid exposure (AAE) normal (NAE) based on pH monitoring study results. aim this was to characterize genes involved in the pathophysiology immune response GERD. Methods This an ...

Moore, Paul E., Thomas Lahiri, Johanne D. Laporte, Trudi Church, Reynold A. Panettieri, Jr., and Stephanie A. Shore. Selected Contribution: Synergism between TNF-a and IL-1b in airway smooth muscle cells: implications for b-adrenergic responsiveness. J Appl Physiol 91: 1467–1474, 2001.—In human cultured airway smooth muscle cells, interleukin (IL)-1b increases cyclooxygenase (COX)-2 expression ...

vitiligo is a pigmentation disorder in which inflammatory mediators such as cytokines have a pivotal role in disease's pathogenesis. interleukin 17 (il-17a) is a proinflammatory cytokine which is involved in the induction of several proinflamatory mediators such as cyclooxygenase 2 (cox2). the aim of this study was to investigate the gene expression of il-17 and cox2 in peripheral blood leukocy...

immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...

The pleiotropic cytokine interleukin 6 (IL-6) is involved in immune cell homeostasis. Additionally, IL-6 expression and signaling in tumor cells have been shown to elicit both protumor and antitumor properties. There is a plethora of mechanistic knowledge regarding how IL-6 signal transduction translates to biological responses. However, there is little understanding as to what factors control ...

Alpha(1)-adrenoceptor subtypes (alpha(1A)-, alpha(1B)-, alpha(1D)-) are known to couple to similar signaling pathways, although differences among the subtypes do exist. As a more sensitive assay, we used oligonucleotide microarrays to identify gene expression changes in Rat-1 fibroblasts stably expressing each individual subtype. We report the gene expressions that change by at least a factor o...

Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the susceptibility to H. pylori or the disease outcomes. But the details and association to different polymorphis...

Because both the brain natriuretic peptide (BNP) gene and the cytokine interleukin-1b (IL-1b) are induced in the infarcted myocardium, localized production of IL-1b may regulate the BNP gene. We tested whether (1) IL-1b regulates the human BNP promoter, (2) cis elements in the proximal promoter respond to IL-1b, and (3) mitogenactivated protein kinase (MAPK) signaling pathways [p42/44, c-jun (J...

Hikiji, Hisako, Wee Soo Shin, Toshiyuki Koizumi, Tsuyoshi Takato, Takafumi Susami, Yoko Koizumi, Yoko Okai-Matsuo, and Teruhiko Toyo-oka. Peroxynitrite production by TNF-a and IL-1b: implication for suppression of osteoblastic differentiation. Am J Physiol Endocrinol Metab 278: E1031–E1037, 2000.—To determine the roles of nitric oxide (NO) and its metabolite, peroxynitrite (ONOO2), on osteoblas...