This paper presents a pseudo-GEE approach to the analysis of longitudinal surveys when the response variable contains missing values. A cycle-specific marginal hotdeck imputation method is proposed to fill in the missing responses and the pseudo-GEE method described in Carrillo et al. (2009) is applied to the imputed data set. Consistency of the resulting pseudo-GEE estimators is established un...

Parkinson's disease (PD) is associated with loss of total glutathione (GSH) which may contribute to progressive cell death. Peripheral GSH administration has been used clinically with reported benefits. Despite this, there is little specific information to characterize its cellular uptake or clearance, brain elevation with peripheral delivery or neuroprotective efficacy in PD models. The curren...

The most commonly used model selection criterion, Akaike’s Information Criterion (AIC), cannot be used when the Generalized Estimating Equations (GEE) approach is considered for analyzing multivariate binary response. Recently, a modified version of AIC (mAIC) which is based on quasi-likelihood function is proposed as a model selection criterion. This model selection criterion can be used in th...

The Generalised Estimating Equations (GEE) proposed by Liang and Zeger (1986) and Zeger and Liang (1986) have found considerable attention in the last ten years and several extensions have been proposed. In this annotated bibliography we describe the development of the GEE and its extensions during the last decade. Additionally, we discuss advantages and disadvantages of the different parametri...

Correlated response data are common in biomedical studies. Regression analysis based on the generalized estimating equations (GEE) is an increasingly important method for such data. However, there seem to be few model-selection criteria available in GEE. The well-known Akaike Information Criterion (AIC) cannot be directly applied since AIC is based on maximum likelihood estimation while GEE is ...

BACKGROUND Connected individuals (or nodes) in a network are more likely to be similar than two randomly selected nodes due to homophily and/or network influence. Distinguishing between these two influences is an important goal in network analysis, and generalized estimating equation (GEE) analyses of longitudinal dyadic network data are an attractive approach. It is not known to what extent su...

BACKGROUND The celebrated generalized estimating equations (GEE) approach is often used in longitudinal data analysis While this method behaves robustly against misspecification of the working correlation structure, it has some limitations on efficacy of estimators, goodness-of-fit tests and model selection criteria The quadratic inference functions (QIF) is a new statistical methodology that o...

Correlated response data often arise in longitudinal and familial studies The marginal regression model and its associated generalized estimating equation GEE method are becoming more and more popular in handling such data Pepe and Anderson pointed out that there is an important yet implicit assumption behind the marginal model and GEE If the assumption is violated and a non diagonal working co...