Since 1991 the European Medicines Agency (EMA, formerly EMEA) adopted the Guidelines of the International Conference onHarmonization (ICH) onGoodClinical Practice (GCP). In this regard, one European Union (EU) Guideline and three EU Directives are in force at present, that is, the E6/CPMP/ICH/135/95 GCP Guideline, Directive 2001/83/EC (Community Codex on Pharmaceuticals), Directive 2001/20/ EC ...

In this paper we are interested in the elaboration of an approached solution to the sum coloring problem (MSCP), which is an NP-hard problem derived from the graphs coloring (GCP). The problem (MSCP) consists in minimizing the sum of colors in a graph. Our resolution approach is based on an hybridization of a genetic algorithm and a local heuristic based on an improvement of the maximal indepen...

The Graph Colouring Problem (GCP) is a well known -hard problem with many theoretical and practical applications. In this paper we introduce a new local search algorithm based on a very large scale neighbourhood. We provide an extensive numerical comparison between this method and several other local search techniques considering also the embedding of the local search into more complex schemes ...

The paper describes an application of Parallel Simulated Annealing (PSA) for solving one of the most studied NP-hard optimization problems: Graph Coloring Problem (GCP). Synchronous master-slave model with periodic solution update is being used. The paper contains description of the method, recommendations for optimal parameters settings and summary of results obtained during algorithm’s evalua...

Our previous studies revealed that the staphylococcal protein Gcp is essential for bacterial growth; however, the essential function of Gcp remains undefined. In this study, we demonstrated that Gcp plays an important role in the modulation of the branched-chain amino acids biosynthesis pathway. Specifically, we identified that the depletion of Gcp dramatically elevated the production of key en...

Generalized Constant Propagation (GCP) statically estimates the ranges of variables throughout a program. GCP is a top-down compositional compiler analysis in the style of abstract intepretation. In this paper we present an implementation of both intraprocedural and interprocedural GCP within the context of the C language. We compare the accuracy and utility of GCP information for several versi...

ABSTRACT The ERA method is a multi-agent oriented method for solving onstraint satisfa tion problems. During problem solving, distributed agents in ERAmake de isions based on their own lo al environments. Although ea h agent has multiple lo al variables and the rea tive behaviors of the agent are lo al, the system an rea h a solution state. In this paper, we introdu e agent ompromises in solvin...

The O-sialoglycoprotein endopeptidase (glycoprotease, Gcp) is secreted by Pasteurella haemolytica A1, a Gram-negative pathogen associated with bovine pneumonic pasteurellosis. When the cloned gcp gene is expressed in Escherichia coli, the recombinant glycoprotease (rGcp) is exported to the periplasm but does not exhibit enzymatic activity. Polyclonal calf sera and murine monoclonal antibodies t...

Gastritis cystica profunda (GCP) is a rare hyperplastic lesion of unclear etiology. Clinical symptoms of GCP are variable and range from nonspeci ic abdominal pain to gastric outlet obstruction. Often the diagnosis of GCP has been dif icult to make as simple esophagogastroduodenoscopy (EGD) guided biopsy can fail to yield the diagnosis. Here, we report a case of GCP that presented in a challeng...

AIMS In this study, our aim was to evaluate the angio-vasculogenic properties of human adipose tissue-derived mesenchymal stem cells overexpressing the granulocyte chemotactic protein (GCP)-2 (hASCs/GCP-2) and to determine possible therapeutic effects in an experimental ischaemic heart model. METHODS AND RESULTS Quantitative real-time (qRT)-PCR results revealed that hASCs/GCP-2 expressed sign...