Recent research into seasonal climate prediction has focused on combining multiple atmospheric general circulation models (GCMs) to develop multimodel ensembles. A new approach to combining multiple GCMs is proposed by analyzing the skill levels of candidate models contingent on the relevant predictor(s) state. To demonstrate this approach, historical simulations of winter (December–February, D...

[1] Variable resolution general circulation models (GCMs) using a global stretched grid with enhanced uniform resolution over the region(s) of interest have proven to be an established approach to regional climate modeling providing an efficient regional downscaling to mesoscales. This approach has been used since the early to mid-1990s by climate modeling groups from France, the United States,...

single-minded (sim) is a master regulatory gene that directs differentiation in the central nervous system during Drosophila embryogenesis. Recent identification of the mesectoderm enhancer (MSE) of sim has led to the hypothesis that two Snail (Sna)-binding sites in the MSE may repress sim expression in the presumptive mesoderm. We provide evidence here that three Sna-binding sites proximal to ...

Smuggling of methamphetamine is affected by enforced regulation and international situation, resulting in changes of precursors and synthetic methods used. Enantiomer ratio of methamphetamine can provide information concerning its precursor and synthetic method. This information is useful for the prevention of smuggling methamphetamine and its precursor, and resultant reduction of methamphetami...

[1] The ability of general circulation models (GCMs) to reproduce the observed strong correlations of Eurasian snow extent in the fall to wave activity and Northern Annular Mode anomalies in the following winter is studied. The observed correlations have been hypothesized to involve two parts: a Rossby wave pulse generated in the troposphere in response to snow-forced surface cooling and a coup...

The general circulation models (GCMs) used to simulate future climate are under-constrained, as evidenced by the fact that factor-of-two changes in rates of ocean heat uptake1, 2, magnitudes of radiative forcing anomalies3, 4, and the strength of various feedbacks5–7 can be traded off against one another to yield results that all agree with observations8, 9. This indeterminacy, although inevita...

In Drosophila, the development of the midline cells of the embryonic ventral nerve cord depends on the function of the bHLH-PAS transcription factor Single-minded (Sim). The expression domain of sim, however, is also found anterior and posterior to the developing ventral cord throughout the germ band. Indeed, mutations in sim were identified based on their characteristic cuticle phenotype. Eigh...

BACKGROUND In most states, mental illness costs are an increasing share of Medicaid expenditures. Specialized depression care managers (CM) have consistently demonstrated improvements in patient outcomes relative to usual primary care (UC), but are costly and may not be fully utilized in smaller practices. A generalist care manager (GCM) could manage multiple chronic conditions and be more acce...

OBJECTIVES The purpose of this study has been to assess ambient bisphenol A (BPA) levels in workplaces and urine levels of workers and to establish a BPA database for different populations in Malaysia. MATERIAL AND METHODS Urine samples were collected from plastic factory workers and from control subjects after their shift. Air samples were collected using gas analyzers from 5 sampling positi...

This study was purposed to investigate the effect of onion or beet on plasma and liver lipids, erythrocyte Na efflux channels and platelet aggregation in simvastatin (SIM) treated hypercholesterolemic rats. Forty Sprague Dawley rats were divided into four groups and fed 0.5% cholesterol based diets containing 2 mg/kg BW simvastatin or simvastatin with 5% onion or beet powder. Plasma total chole...