BACKGROUND Global Health Initiatives (GHIs) respond to high-impact communicable diseases in resource-poor countries, including health systems support, and are major actors in global health. GHIs could play an important role in countries affected by armed conflict given these countries commonly have weak health systems and a high burden of communicable disease. The aim of this study is to explor...

OBJECTIVES The Global Alliance for Vaccines and Immunization (GAVI) anticipated that growing demand for new vaccines could sufficiently impact the vaccines market to allow low-income countries (LICs) to self-finance new vaccines. But the time required to lower vaccine prices was underestimated and the amount that prices would decline overestimated. To better understand how prices in the LIC vac...

BACKGROUND Substantial resources have been invested in increasing childhood immunisation coverage through global initiatives such as the Universal Childhood Immunisation (UCI) campaign and the Global Alliance on Vaccines and Immunisations (GAVI). There are longstanding concerns that target-oriented and performance-oriented initiatives such as UCI and GAVI's immunisation services support (ISS) m...

Background Global health partnerships have grown rapidly in number and scope, yet there has been less emphasis on their evaluation. Gavi, the Vaccine Alliance, is one such public-private partnership; in Gavi-eligible countries partnerships are dynamic networks of immunization actors who work together to support all stages and aspects of Gavi support. This paper describes a conceptual framework ...

OBJECTIVE To evaluate stakeholders' understanding and opinions of the International Finance Facility for Immunisation (IFFIm); to identify factors affecting funding levels; and to explore the future use of IFFIm. METHODS Between July and September 2015, we interviewed 33 individuals from 25 organizations identified as stakeholders in IFFIm. In total 22.5 hours of semi-structured interviews we...

Equity monitoring is a priority for Gavi, the Vaccine Alliance, and for those implementing The2030 agenda for sustainable development. For its new phase of operations, Gavi reassessed its approach to monitoring equity in vaccination coverage. To help inform this effort, we made a systematic analysis of inequalities in vaccination coverage across 45 Gavi-supported countries and compared results ...

316 www.thelancet.com Vol 378 July 23, 2011 is substan tial (3·8 million disabilityadjusted life-years [DALYs]), it ranks well behind that of other vaccinepreventable diseases such as tetanus (8·3 million DALYs) and measles (23 million DALYs). Second, the eff ectiveness of the HPV vaccine against cervical cancer is still unknown. This uncertainty concerns African populations in particular, with...

Perspectives The international community has successfully promoted childhood vaccination as an essential public health intervention. This has been accomplished through efforts such as the World Health Organization's (WHO) Expanded Programme on Immunization and more recently, the establishment of the Global Alliance for Vaccines and Immunization (GAVI Alliance), a global health partnership commi...

BackgroundMiddle-income countries (MICs) that are not eligible for funding from Gavi, the Vaccine Alliance, have been slow to adopt rotavirus vaccines. Few studies evaluated cost-effectiveness and benefit–risk of vaccination in these settings. We aimed assess potential economic health impact 63 MICs Gavi.MethodsIn this modelling study, we estimated Gavi funding. used an Excel-based proportionat...

In recent years, the private and public sectors have increased investments in medical diagnostics for low- and middle-income countries (LMICs). Despite these investments, numerous barriers prevent the adoption of existing diagnostics and discourage the development and introduction of new diagnostics in LMICs. In the late 1990s, the global vaccine community had similar challenges, as vaccine cov...