EDITORIAL article Front. Oncol., 08 August 2023Sec. Gastrointestinal Cancers: Colorectal Cancer Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1260158

cancer and the intestinal type of gastric cancer usually follows stepwise progression with recognizable pre-neoplastic changes (i.e., adenoma and intestinal metaplasia for colorectal and gastric cancers, respectively). Therefore, screening and early diagnosis remain the preferred options to ease the disease burden. Surgical resection is the mainstay treatment for gastrointestinal cancers. Other...

BACKGROUND Although, family history of cancer is an important risk factor for upper gastrointestinal cancers development, but limited information is available on the upper gastrointestinal cancers associated with family history in Iran. The purpose of this study was to define upper gastrointestinal cancers risk associated with family history of cancer. METHODS This study was conducted as a ca...

Aiwu Ruth Hea,∗, Jonathan Mendelsonb, Tiffany Blakeb, Lopa Mishrab,c and John L. Marshalla Division of Hematology/Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA Laboratory of Cancer Genetics, Digestive Diseases, and Developmental Molecular Biology, Department of Surgery, Lombardi Cancer Center, Georgetown University, Washington, DC, USA Laboratory of ...

Despite progress in the management of gastrointestinal malignancies, these diseases remain devastating maladies. Conventional treatment with chemotherapy and radiation is still only partially effective and highly toxic. In the era of increasing knowledge of the molecular biology of tumors and the interaction between the tumor and immune system, the development of targeted agents, including canc...

Epigenetic alterations, including DNA methylation, histone modifi cation, loss of genome imprinting, chromatin remodeling and non-coding RNAs, are associated with human carcinogenesis. Among them, DNA methylation is a fundamental epigenetic process to modulate gene expression. In cancer cells, altered DNA methylation includes hypermethylation of site-specifi c CpG island promoter and global DNA...

Gastrointestinal malignancies are challenging cancers with considerable economic and societal impacts on health care systems worldwide. While advances in surgical approaches have provided benefits to a proportion of patients, only modest improvements have been attained in the treatment of patients with advanced disease, resulting in limited improvement in survival rates in these patients. Oncol...