TAHRE, the least abundant of the three retrotransposons forming telomeres in Drosophila melanogaster, has high sequence similarity to the gag gene and untranslated regions of HeT-A, the most abundant telomere-specific retrotransposon. Despite TAHRE's apparent evolutionary relationship to HeT-A, we find TAHRE Gag cannot locate to telomere-associated "Het dots" unless collaborating with HeT-A Gag...

Glycosaminoglycans (GAGs) have been identified as one of the macromolecules present in the stone matrix. Although electrophoresis has been used to analyze the composition of GAGs, this method is laborious and insensitive. The aim of this study was to examine GAG profiles in the stone matrix from 4 types of stones using high-performance liquid chromatography (HPLC). This method has been shown to...

Glycosaminoglycans (GAGs) are linear, highly negatively charged polysaccharides. They are ubiquitous molecules exhibiting a wide range of biological functions with numerous applications in pharmaceutical, cosmetic, and nutraceutical industrials. The commercial fish-processing industry generates large quantities of solid waste, which can represent a potential resource for GAG production. In this...

This article describes a simple and selective procedure used for direct measurement of sulfated glycosaminoglycans (GAGs) in biological samples and its application to the determination of GAGs during tissue regeneration and myogenic differentiation. We describe a modified procedure of previous GAG assays that has improved specificity, reproducibility, and sensitivity. The assay is based on the ...

s-The uronic acid-containing glycosaminoglycans present in the brains of rat, monkey, chicken, sheep and rabbit were isolated into various fractions by combining the cetyl pyridinium procedure and DEAE-Sephadex column Chromatography. The analyses of the fractions show that hyaluronic acid, chondroitin4sulphate, chondroitin-6-sulphate, heparan sulphate and a testicular hyaluronidase-resistant ga...

The present study was aimed to extract the Glycosaminoglycans (GAGs) from shrimp head waste and carry out analysis for any antimicrobial activity against Escherichia coli Staphylococcus aureus. are linear acidic polysaccharides with repeating disaccharide units. GAGs important cell signaling, which controls a wide range of metabolic activities including regulation growth, promotion adhesion, wo...

Amyloidosis is a protein folding disorder in which normally soluble proteins are deposited extracellularly as insoluble fibrils, impairing tissue structure and function. Charged polyelectrolytes such as glycosaminoglycans (GAGs) are frequently found associated with the proteinaceous deposits in tissues of patients affected by amyloid diseases. Experimental evidence indicate that they can play a...

Cathepsin K, a lysosomal papain-like cysteine protease, forms collagenolytically highly active complexes with chondroitin sulfate and represents the most potent mammalian collagenase. Here we demonstrate that complex formation with glycosaminoglycans (GAGs) is unique for cathepsin K among human papain-like cysteine proteases and that different GAGs compete for the binding to cathepsin K. GAGs p...

Glycosaminoglycans (GAGs) are long and unbranched anionic heteropolysaccharides that have been associated with virtually all amyloid deposits. Soluble sulfated GAGs known for their propensity to promote the self-assembly of numerous amyloidogenic proteins modulate cytotoxicity. Nonetheless, although prevalent on outer leaflet eukaryotic cell plasma membrane as part proteoglycans, contributions ...

Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory disease of connective tissue with unknown etiology. We investigated whether aberrant immune responses to glycosaminoglycans (GAGs), a major component of joint cartilage, joint fluid, and other soft connective tissue, causes this disease. Here we show that injection of GAGs such as hyaluronic acid, heparin, and chondroitin sulfat...