Accurate diagnosis in early stage is vital for the treatment of Hepatocellular carcinoma. The aim of this study was to investigate the potential of poly lactic acid-polyethylene glycol/gadolinium-diethylenetriamine-pentaacetic acid (PLA-PEG/Gd-DTPA) nanocomplexes using as biocompatible molecular magnetic resonance imaging (MRI) contrast agent. The PLA-PEG/Gd-DTPA nanocomplexes were obtained usi...

Centro Nacional Patagónico, Casilla de Correo 128, Puerto Madryn, Chubut, Argentina (UFJP) Laboratorio de Evolución, Facultad de Ciencias, Universidad de la República, Igúa 4225, Montevideo, Uruguay (GD) División Biologı́a, Jardı́n Zoológico y Botánico de La Plata, Calles 52 y 118, 1900 La Plata, Buenos Aires, Argentina (SC) Laboratorio de Genética Evolutiva y Molecular, Facultad de Ciencias Exac...

Alkyl polyglucosides, due to their low toxicity and environmental compatibility, could be used in biodegradation of hydrophobic compounds. In this study, the influence of Lutensol GD 70 on the cell hydrophobicity and zeta potential was measured. The particle size distribution and surfactant biodegradation were also investigated. Microbacterium sp. strain E19, Pseudomonas stutzeri strain 9, and ...

This study describes the first case of biliary peritonitis after radiofrequency ablation diagnosed by magnetic resonance (MR) imaging with gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA), a hepatocyte-specific MR imaging contrast agent. The image acquired 300 minutes after the administration of Gd-EOB-DTPA was useful to make a definite diagnosis and to identify the path...

A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N',N",N"-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded regio...

Twenty-six patients with suspected lesions of the spinal cord were studied before and after administration of gadolinium-DTPA to assess whether contrast enhancement was useful in the MR evaluation of intramedullary disease. Nine patients had primary tumors, six had benign syringes, three had multiple sclerosis with cord involvement, three had thrombosed vascular malformations, three had probabl...

OBJECTIVE To examine the relation between rate of synovial membrane enhancement, intra-articular pressure (IAP), and histologically determined synovial vascularity in rheumatoid arthritis, using gadolinium-DTPA enhanced magnetic resonance imaging (MRI). METHODS Dynamic gadolinium-DTPA enhanced MRI was performed in 31 patients with knee synovitis (10 patients IAP study, 21 patients vascular mo...

Gadolinium neutron capture therapy (Gd-NCT) is an experimental cancer treatment based on the physical principal that neutron capture by gadolinium-157 ensures the release of focal high-dose radiation, such as Á-rays and electrons. Survival and induction of chromosomal aberrations of human SW-1573 cells was studied after thermal neutron irradiation without and with gadolinium. After neutron irra...

The diagnostic value of gadolinium-DTPA (diethylenetriamine penta-acetic acid) enhanced magnetic resonance imaging in patients treated by thrombolysis for acute myocardial infarction was assessed in 27 consecutive patients who had a first acute myocardial infarction (14 anterior, 13 inferior) and who underwent thrombolytic treatment and coronary arteriography within 4 hours of the onset of symp...

While research exploring the utility of intravascular gadolinium based contrast agents (GBCA), such as gadofosveset (Vasovist, ABLAVAR) is ongoing, cardiac MR is currently routinely performed with administration of standard extracellular GBCAs, e.g. Gd-DTPA (Magnevist) or Gd-BOPTA (Multihance). LGE is a phenomenon related to the distribution of the extracellular GBCAs. Upon intravenous injectio...