The whisker-to-barrel system of adult mice was used in a study on the effects of short-lasting tactile stimulation and sensory conditioning training on GABAA receptor binding in the barrel field of somatosensory cortex. In vitro receptor binding autoradiography was used to examine the pattern and intensity of [3H]muscimol binding to GABAA receptors. A well-defined pattern of GABAA receptors in ...

αβγ GABAA receptor currents are phasic and desensitizing while αβδ GABAA receptor currents are tonic and have no fast desensitization. αβγ receptors are subsynaptic and mediate phasic inhibition while αβδ receptors are extra or peri-synaptic and mediate tonic inhibition. Given the different roles of these GABAA receptor isoforms and that GABAA receptors are allosterically regulated by extracell...

In the CNS, gamma-aminobutyric acid (GABA) affects neuronal activity through both the ligand-gated GABAA receptor channel and the G protein-coupled GABAB receptor. In the mature nervous system, both receptor subtypes decrease neural excitability, whereas in most neurons during development, the GABAA receptor increases neural excitability and raises cytosolic Ca2+ levels. We used Ca2+ digital im...

Sadeghi H, Taylor HS. HOXA10 regulates endometrial GABAA receptor expression and membrane translocation. Am J Physiol Endocrinol Metab 298: E889 –E893, 2010. First published January 26, 2010; doi:10.1152/ajpendo.00577.2009.—Expression of the GABAA receptor has been described previously in the human endometrium in both luminal epithelium and stroma. Its expression is increased during decidualiza...

Feng, Hua-Jun and Robert L. Macdonald. Proton modulation of 1 3 GABAA receptor channel gating and desensitization. J Neurophysiol 92: 1577–1585, 2004. First published May 19, 2004; 10.1152/jn.00285.2004. GABAA receptor currents are phasic and desensitizing, whereas GABAA receptor currents are tonic and have no fast desensitization. receptors are subsynaptic and mediate phasic inhibition, wherea...

The inhibitory neurotransmitter !-aminobutyric acid (GABA) has multiple receptors. In mammals, the GABAA receptor subtype is modulated by neurosteroids. However, whether steroid interaction with the GABAA receptor is unique to mammals or a conserved feature in vertebrates is unknown. Thus, neurosteroid modulation of the GABAA receptor was investigated in the brain of the bullfrog (Rana catesbei...

GABAA receptors mediate fast phasic inhibitory postsynaptic potentials and participate in slower tonic extrasynaptic inhibition. Thy1alpha6 mice with ectopic forebrain expression of GABAA receptor alpha6 subunits exhibit increased extrasynaptic GABAA receptor-mediated background conductance and reduced synaptic GABAA receptor currents in hippocampal CA1 neurons [W. Wisden et al. (2002) Neuropha...

...........................................................................................viii Abbreviations used in text....................................................................xi CHAPTER 1: General Introduction.........................................................1 I. Cardiac Arrest and Cerebral Ischemia............................................1 II. The Cerebellum and Purkin...