in this research,qsar study has been carried out on quinolizidinyl derivatives as potent inhibitors of acetyl and butyrylcholin esterase in alzheimer’s disease. despite significant research efforts in both industry and academia, there are currently no diseases modifying therapies available to treat this illness. significant evidence suggests that the pathology of ad is linked to generation of β...

The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitors can be used to efficiently target it. In the present study, the multiple linear regression (MLR), and support vector machine (SVM) methods were used to interpret the chemical structural functionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structural information were described ...

In this research,QSAR study has been carried out on quinolizidinyl derivatives as potent inhibitors of Acetyl and Butyrylcholin esterase in Alzheimer’s disease. Despite significant research efforts in both industry and academia, there are currently no diseases modifying therapies available to treat this illness. Significant evidence suggests that the pathology of AD is linked to generation of β...

Salt lakes on the Tibetan Plateau (TP) are rich in lithium (Li), boron (B) and other mineral resources, accurate assessment of content spatial distribution brine those salt is important to guide development utilization their resources. There few studies estimating TP due lack situ investigation data. This study introduced an intelligent prediction model combining a feature selection algorithm w...

Reported values of lung resistance (RL) and elastance (EL) in spontaneously breathing preterm neonates vary widely. We hypothesized that this variability in lung properties can be largely explained by both inter- and intrasubject variability in breathing pattern and demographics. Thirty-three neonates receiving nasal continuous positive airway pressure [weight 606-1,792 g, gestational age (GA) ...

A new hybrid method called GA-SVM was proposed which combines GA (Genetic Algorithm) as a feature selection model and SVM (Support Vector Machine) as a regression model. With some modifications to the general GA and SVM models, this method can implement feature selection and activity prediction simultaneously, and its performance can be improved. Two experiments are carried out which indicate i...

The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitorscan be used to efficiently target it. In the present study, the multiple linear regression (MLR),and support vector machine (SVM) methods were used to interpret the chemical structuralfunctionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structuralinformation were described thro...

The 17β-HSD3 enzyme plays a key role in treatment of prostate cancer and small inhibitorscan be used to efficiently target it. In the present study, the multiple linear regression (MLR),and support vector machine (SVM) methods were used to interpret the chemical structuralfunctionality against the inhibition activity of some 17β-HSD3inhibitors. Chemical structuralinformation were described thro...

Lithium-ion batteries are the current most promising device for electric vehicle applications. They have been widely used because of their advantageous features, such as high energy density, many cycles, and low self-discharge. One critical factors correct operation an is estimation battery charge state. In this sense, work presents a comparison state (SoC), tested in four different conduction ...