background: most cancer cells become resistant to anti-cancer agents. in the last few years, a new approach for targeted therapy of human cancer has been developed using immunotoxins which comprise both the cell targeting and the cell killing moieties. methods: in the present study, the recombinant shiga toxin a1 subunit fused to human granulocyte-macrophage colony stimulating factor (a1-gm-csf...

distal junctional kyphosis (djk) is a radiographic finding in patients that undergo spinal instrumentation and fusion, since there is an abrupt transition between fixed and mobile spinal segments.the true incidence of djk is variable in literature and seems that has a multifactorial etiology. a consecutive series of 130 patients (mean age 15.6 years) with adolescent idiopathic scoliosis who und...

tooth fusion is a developmental anomaly characterized by the :union: between the dentin and/or enamel of at least two separately developing teeth. the fusion of posterior teeth is an uncommon occurrence. in this article, we report a rare case of unilateral fusion of a mandibular second molar with a paramolar. carious exposure mandated endodontic treatment. the unusual morphology and complex roo...

introduction: reverse transcriptase-polymerase chain reaction (rt-pcr) assay is a useful tool for the detection of fusion transcript resulting from specific chromosomal translocation of the leukemia cells. a specific chromosomal abnormality, the philadelphia chromosome (ph), is present in 90% to 95% of cml patients.the aberration results from a reciprocal translocation between chromosome 9 and ...

splenogonadal fusion is a rare congenital malformation whereby the splenic tissue is found attached or surrounded by the testis, and presents in both continuous and discontinuous forms. splenogonadal fusion may be misinterpreted as a primary malignant testicular or an adenomatoid tumor. knowledge about the existence of such an entity is essential in order to preserve the testis during surgical ...

background & importance: spinal deformity is one of the most common disorders among the vertebral diseases that results from unnatural curvatures of spine, such as scoliosis and kyphosis. spinal fusion surgery used most commonly to treat certain types of spinal deformity. here in, we report the efficacy of posterior spinal fusion accompanied by instrumentation in patients with the limitations o...

Background: The Philadelphia chromosome (Ph) characterized by t (9; 22) (q34; q11.2) is a reciprocal translocation giving rise to a chimeric BCR-ABL fusion gene. Incidence of Ph chromosome is over 98% in Patients with Chronic Myeloid Leukemia (CML) and around 20% in acute lymphoblastic leukemia (ALL). The finding of this fusion gene is essential for diagnosis of CML by detection of various fusi...

background & aim: the purpose of this study was to evaluate and compare the pain of patients with spondylolisthesis who had undergone either of the surgery techniques: posterolateral fusion (plf) or posterior lumbar interbody fusion (plif). methods & materials/patients: in a prospective observational study, 102 surgical candidates with low grade degenerative and isthmic spondylolisthesis were e...