Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein and/or CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of rutaceae and umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from pla...

Furanocoumarins in grapefruit are known to show inhibitory effects against P-glycoprotein (P-gp) and CYP3A4 in intestinal epithelial cells; however, furanocoumarin derivatives are widely contained in the plants of Rutaceae and Umbelliferae families, which are used as components of Kampo extract medicines. In this study, we investigated the inhibitory effects of 12 furanocoumarins extracted from...

Real-time fluorescence detection systems were adapted to identify DNA adducts formed by photogenotoxic phytochemicals. Two assays were developed: the first was based on quantitative polymerase chain reaction (qPCR) while the second used thermal denaturation and renaturation (D-R). Both assays employed yeast DNA, the fluorescent dye SYBR Green and a real-time PCR thermocycler. The furanocoumarin...

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of genera Boenminghausenia, Clausena Ruta. The distribution these compounds appears to be restricted plants family Rutaceae. To date, there have been a consider...

objective(s) as an important class of natural products, coumarins exhibit many biological activities and the diversity of their bioactivity is so huge that the pharmacological promiscuity has been applied on their case. oxypeucedanine also named as prangolarin is a linear furanocoumarin with an oxygenated prenylated substitution at c-5 of the nucleus. to our knowledge, there are few reports on ...

Feroniellin analogs isolated from Feroniella lucida possess a furanocoumarin skeleton connected to monoterpenic five- seven-membered ethereal rings by an ether linkage and exhibit broad spectrum of biological activities. In this contribution, we intended establish “ring-size-divergent” synthetic strategy for the through chemical sythesis feroniellins. The short comprehensive synthesis feroniell...

Grapefruit juice has been found to cause an increase in the oral bioavailability of many therapeutic agents. Such interactions are believed to result from the mechanism-based inhibition of CYP3A4 activity in the intestine. Furanocoumarin dimers present in the juice have been found to be extremely potent inhibitors of CYP3A4 activity. The aim of this work was to synthesize and test a series of d...