We present an approach to the admission control, resource allocation and routing problem in connection-oriented networks that o¤er multiple services to users. Users’ preferences are summarized by means of their utility functions, and each user is allowed to request more than one type of service. Each requested service may be delivered over one of many possible routes. Multiple types of resource...

We consider single-hop all-optical networks in which wavelength-routed connections (lightpaths) between source-destination pairs are dynamically established and torn down in response to a random pattern of arriving connection requests and connection holding times. A connection request may be blocked if no wavelength is available on a suitable path from source to destination. For these networks ...

Collaborative authoring tools generate network effects, where each tool's value depends not just on the tool itself, but on the number of other people who also have compatible tools. We hypothesize that the best way to generate network effects and to add collaborative authoring capability to existing tools is to focus on the network protocol. This paper explores a protocol-centric approach to c...

The intrinsic Helmholtz free energy, commonly used as a basis for density functional theories, is here given explicitly as a cluster diagram expansion with density field points. Also given are explicit variational procedures for determining the chemical potential for a given density, the pair potential for a given pair correlation function, and the pair correlation function for a given pair pot...

Protein trafficking and translocation are essential processes in even the simplest living cells. The compartmentalisation within eukaryotic cells places a very high demand on the fidelity of protein trafficking and translocation, since a large percentage of the cell's protein complement is inserted into, or translocated across membranes. Indeed, most mitochondrial proteins are imported from the...

Histone acetylation and methylation are linked to a variety of nuclear activities, most notably transcriptional regulation. Both synergistic and antagonistic relationships between these two modifications have been reported in different systems. Here we show that the budding yeast histone H4 arginine 3 (R3) methyltransferase Hmt1p binds acetylated histones H3 and H4, and importantly, that acetyl...

Histone methylation plays key roles in regulating chromatin structure and function. The recent identification of enzymes that antagonize or remove histone methylation offers new opportunities to appreciate histone methylation plasticity in the regulation of epigenetic pathways. Peptidylarginine deiminase 4 (PADI4; also known as PAD4) was the first enzyme shown to antagonize histone methylation....