The aim of this study was to investigate the process transfer of a commercially available product from the current batch fluid bed granulation and drying production method to an innovative continuously operating "from powder to tablet" production line using twin screw granulation as an intermediate granulation step. By monitoring process outcomes (torque, water temperature at the granulator jac...

Bilayer tablets of aceclofenac sodium were developed using carboxymethylated white yam (Dioscorea rotundata) starch (CWY) for a fast release layer (2.5, 5.0, and 7.5% w/w), and acid-hydrolyzed bitter yam (Dioscorea dumetorum) starch (ABY) for a sustaining layer (27% w/w). Sodium starch glycolate (SSG) and hydroxypropyl methyl cellulose (HPMC) were used as standards. The starches were characteri...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

Objective: This study was employed to evaluate the quality of marketed oral tablets containing clopidogrel bisulfate. Tablets produced by various companies and commercialized in Iraq market were used study. Methods: Batches bisulfate conventional (containing 75 mg drug) exposed control tests. These tests involved friability, weight variation, hardness, drug content, disintegration time, vitro r...

Both the Valsartan (VAL) and Olmesartan medoxomil (OLM) are widely prescribed anti-hypertensive agents with angiotensin II type I receptor antagonistic activity. VAL OLM of BCS class drugs having a low variable oral bioavailability. Recrystallization from different organic solvents improved its aqueous solubility thereby in vitro dissolution properties. In present investigation, tablets contain...

Objective: The objective of the present study was to formulate piperazine citrate tablets using natural aloe vera gum as a binding agent and evaluate tablets. Methods: extracted used for preparation tablets, characteristics are compared with an equivalent amount acacia sodium carboxymethyl cellulose (NaCMC) in different formulations Three batches were prepared (F1), NaCMC (F2), (F3) agents. ass...

Litter is the main source of ammonia (NH3) in broiler houses. The quality thereof affects amount NH3 volatilized and emitted from house as well welfare birds. A trial was conducted to determine how addition water litter (by spraying surface) raking or leaving undisturbed will influence concentrations at level, composition, bird welfare, performance under experimental conditions. total 2160 Ross...