Bone fracture is a global healthcare issue for high rates of delayed healing and nonunions. Although n-3 polyunsaturated fatty acid (PUFA) is considered as a beneficial factor for bone metabolism, only few studies till date focused on the effects of n-3 PUFAs on fracture healing. In this study, we investigated the effect of endogenous n-3 PUFAs on fracture healing by measuring femur fracture re...

Those of us who have experienced a significant fracture likely recall first the pain of the injury, then we often focus our attention on the prospect of time in a cast or other form of extended immobilization. We imagine the discomfort and limitations that will ensue, and after all else settles down, we often wonder, “How strong are my bones anyway, and will I fracture again?” Nature, on the o...

Introduction: The blood supply as well as mechanical factors are known to guide the fracture healing process [1-4]. Revascularization, tissue differentiation and local mechanical conditions depend on each other in a very complex manner. Mathematical models have been developed to describe the time dependent callus formation during fracture healing. [5-8]. However, previous models did not take in...

Metaphysis cancellous bone fracture is one of the most common fracture types in clinical orthopedic practice. The specialized healing process of cancellous bone fracture has long been ignored by the academic society. Comparing with diaphyseal cortical bone healing, cancellous bone healing showed less bone tissue necrosis, barely any hematoma formation, limited inflammation events and no externa...

PURPOSE OF REVIEW This review summarizes research on the physiological changes that occur with aging and the resulting effects on fracture healing. RECENT FINDINGS Aging affects the inflammatory response during fracture healing through senescence of the immune response and increased systemic pro-inflammatory status. Important cells of the inflammatory response, macrophages, T cells, mesenchym...

INTRODUCTION Fracture healing is a complex process influenced by intrinsic and extrinsic factors. The aim of the present study was to evaluate the effects of botulinum toxin (BTX) A on fracture healing. MATERIALS AND METHODS Following the induction of bilateral standard closed femoral fractures and relative fixation in 18 Wistar albino rats, 8 IU of BTX A were injected into the right femoral ...

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OBJECTIVE Investigate whether intervention with GH after tibial fracture enhances fracture healing. DESIGN Randomised, double-blind, placebo-controlled study in 406 patients (93 women, 313 men, age: 18-64 years) with tibial fracture. METHODS Patients were stratified by tibial fracture (open or closed) and allocated to placebo or GH treatment (15, 30 or 60 mug/kg daily, until clinically asse...

This systematic review examines the efficacy and safety of whole body vibration (WBV) on fracture healing. A systematic literature search was conducted with relevant keywords in PubMed and Embase, independently, by two reviewers. Original animal and clinical studies about WBV effects on fracture healing with available full-text and written in English were included. Information was extracted fro...

Following bone fracture, the repair process starts with an inflammatory reaction at the fracture site. Fracture healing is disturbed when the initial inflammation is increased or prolonged, whereby, a balanced inflammatory response is anticipated to be crucial for fracture healing, because it may induce down-stream responses leading to tissue repair. However, the impact of the immune response o...