PURPOSE To assess the relationship between foveal pit morphology and size of the foveal avascular zone (FAZ). METHODS Forty-two subjects were recruited. Volumetric images of the macula were obtained using spectral domain optical coherence tomography. Images of the FAZ were obtained using either a modified fundus camera or an adaptive optics scanning light ophthalmoscope. Foveal pit metrics (d...

Parafoveal-on-foveal priming refers to the presentation of an item (the prime) in parafoveal vision followed by the presentation of an item (the target) in foveal vision. In natural reading, the 'parafoveal preview benefit' subserves fluent reading as, e.g., reading times increase when such information is not available. Yet, the neural correlates of reading are mostly studied with foveally pres...

Inner foveal thinning and intracellular alpha-synuclein were demonstrated in the retina in Parkinson disease. While pathognomonic alpha-synuclein is associated with embryonic dopaminergic (DA) neurons, postmortem studies in the nervous system and retina show prominent effect also in non-DA neurons. We evaluated foveal capillaries and foveal thickness in 23 Parkinson disease subjects and 13 heal...

PURPOSE To determine the origin of the tapetal-like reflex (TLR) in carriers of X-linked retinitis pigmentosa. METHODS Spectral fundus reflectance of carriers of X-linked retinitis pigmentosa was measured and compared with that of normal subjects. The influence of visual pigment was determined by measuring the density difference, that is, the difference between the logarithmically scaled spec...

PURPOSE To mathematically analyze anatomical changes that occur in the normal fovea during aging. METHODS A total of 2912 spectral-domain optical coherence tomography (SD-OCT) normal foveal scans were analyzed. Subjects were healthy individuals, aged 13 to 97 years, with visual acuity ≥20/40 and without evidence of foveal pathology. Using automated symbolic regression software Eureqa (version...

Recent neuroimaging evidence suggests that visual inputs arising beyond the fovea can be 'fed back' to foveal visual cortex to construct a new retinotopic representation. However, whether these representations are critical for extra-foveal perception remains unclear. Using transcranial magnetic stimulation we found that relatively late (350-400 msec) disruption of foveal retinotopic cortex impa...

Recent neuroimaging evidence suggests that visual inputs arising beyond the fovea can be 'fed back' to foveal visual cortex to construct a new retinotopic representation. However, whether these representations are critical for extra-foveal perception remains unclear. Using transcranial magnetic stimulation we found that relatively late (350-400msec) disruption of foveal retinotopic cortex impai...

BACKGROUND The existence and function of unilateral hemispheric projections within foveal vision may substantially affect foveal word recognition. The purpose of this research was to reveal these projections and determine their functionality. METHODOLOGY Single words (and pseudowords) were presented to the left or right of fixation, entirely within either foveal or extrafoveal vision. To maxi...