Introduction. Ibrutinib is commonly used for the treatment of patients with CLL in either first-line or relapsed/refractory settings. Case Presentation. We present the case of a 74-year-old Caucasian man with CLL who presented with penile gangrene upon initiation of ibrutinib treatment. Our case is the first showing the complication of penile gangrene associated with ibrutinib use. The gangrene...

Hospital Physician January 2008 39 S pontaneous gangrene of the scrotum was described for the first time in 1753 by Boerhaave,1 who reported on a 40-year-old man with urinary retention. Since that time, several authors have reported similar cases of spontaneous gangrene of the scrotum and penis with associated diseases such as systemic infections, diabetes, urinary extravasations and infiltrati...

When World War II began, some of the experimental results obtained on animals indicated that sulfonamides applied locally and taken by mouth might prevent infections with anaerobes of the gas gangrene group. It became evident, even in the Western Desert and Tunisia, that anaerobic infections would occur in spite of sulfonamide prophylaxis. When the fighting took place on the more cultivated soi...

Fournier's gangrene, rare but life threatening disease, is characterized by an acute necrotic infection of the scrotum, penis, or perineum. Fournier's gangrene is a mixed infection caused by both aerobic and anaerobic bacteria. Fournier's gangrene caused by multidrug resistant Acinetobacter baumannii have been reported rarely. The mainstay of treatment is prompt recognition and a combination of...

conclusions traumatic abdominal wall hernia tawh, although uncommon, is associated with significant rate of morbidity and mortality in cases of delayed diagnosis and intervention. early intervention leads to a significantly better outcome. introduction acute abdominal wall rupture with visceral herniation due to blunt traumas and bowel incarceration or perforation are generally rare phenomena. ...

Fournier’s gangrene is a necrotising fasciitis of the genitalia. Jean Alfred Fournier (18321914) was the first French syphilologist, the first professor of cutaneous and syphilitic diseases at the Paris Faculty of Medicine, and the most prominent European venereologist of the second half of the 19th century. He first described idiopathic, rapily progressive necrotizing gangrene of the male geni...

Peripheral gangrene, characterized by distal ischemia of the extremities, is a rare complication in patients with falciparum malaria. Patients with this complication have generally undergone early amputation of the affected areas. In this report, we describe 3 adult Thai patients presented at the Hospital for Tropical Diseases, Bangkok, with high grade of fever ranged 6-9 days, jaundice, acute ...

Fournier's gangrene is the necrotizing fasciitis of perianal, genitourinary, and perineal regions. Herein, we present a case of scrotal Fournier's gangrene as a postoperative complication of inguinal hernia repair. A 51-year-old male with giant indirect hernia is presented. Patient underwent inguinal hernia repair, and after an unproblematic recovery period, he was discharged. He applied to our...

Gas gangrene is one of the most serious infections of traumatic and surgical wounds. The importance lies in the fact that, if not managed at the right time, the condition is fatal. Though perianal cellulitis and gangrene are commonly reported in immunocompromised patients, we report the case of a patient with gas gangrene involving only the anal canal extending to the rectum, a rare presentatio...

Fournier’s gangrene (FG) is a fulminant and life-threatening disease characterized by necrotizing fascitis of the perineal and genitourinary area resulting from polymicrobial infection. The polymicrobial organisms cause ascending reactions, activating various proteins and enzymes, leading to platelet aggregation, intravascular coagulation, tissue ischemic tissue change. This disease rapidly pro...