Anti histaminic activity of cissus quadrangularis stem powder was carried out determining the histamine activity and histamine content in carrageenin induced rat paw swelling model and formalin induced peritonitis respectively. The crude powder at the dose of 100mg/1QQ00 gm exerted reduction to the maximum of 44% in the early hisamine phase swelling. Further it significantly reduced the histami...

objective(s): there are many reports about the role of rostral ventromedial medulla (rvm) in modulating stress-induced analgesia (sia). in the previous study we demonstrated that temporal inactivation of rvm by lidocaine potentiated stress-induced analgesia. in this study, we investigated the effect of permanent lesion of the rvm on sia by using formalin test as a model of acute inflammatory pa...

In this study, the effects of subcutaneous (SC) injection of pilocarpine (a cholinomimetic agent) and atropine (a muscarinic receptors antagonist) were investigated on a tonic model of orofacial pain in rats. The contribution of the endogenous analgesic opioid system was assessed using naloxone (an opioid receptors antagonist). Tonic orofacial pain was induced by SC injection of a diluted forma...

introduction: mineral trioxide aggregate (mta) is an endodontic material with different clinical applications e.g. root-end filling, pulp capping and perforation repair.  it has been reported to possess antimicrobial and antifungal activities. the aim of this study was to examine the effect of white mta on formalin-induced hyperalgesia in a rat with inflammatory pain. materials and methods: inf...

the effect of blood glucose level changes induced by 24h food deprivation and intraperitoneal (ip) injection of insulin (2iu/kg) and glucose (2gr/kg) was investigated on the pain induced by intraplantar (ipl) injection of formalin (20ml , 5%) in mice. blood glucose level changes were determined by blood sampling from the apex of the tail of mice. ip injection of insulin and 24h food deprivation...

calcium, through its various channels involves in local, spinal and supra-spinal transmission of pain. in the present study, we investigated the separate and combined treatment effects of verapamil (a calcium channel blocker), morphine (an opioid agonist) and naloxone (an opioid antagonist) on pain in the orofacial region of rats. orofacial pain was induced by subcutaneous (sc) injection of for...

objectives: the study was carried out to assess the analgesic, anti-inflammatory, and cns depressant activity of the methanolic extract of  the lawsonia inermis barks(melib). materials and methods: anti-inflammatory effects of mebli were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. analgesic activity was measured using acetic acid-induced wr...

1. In this study mast cells were found to comprise 2.1% of total cells recovered by enzymatic digestion of human lung tissue. 2. This mast cell population consisted of 79% formalin-sensitive, Alcian Blue-positive mast cells and 21% formalin-insensitive, Alcian Blue-positive mast cells. 3. By the use of centrifugal elutriation and subsequent Percoll gradient centrifugation, separate mixed cell p...