Non-crystallographic symmetry (NCS) averaging is a well known method for improving the quality of an electron-density map and thus aiding structure determination. Prior methods of NCS-operator determination based on estimated heavy-atom positions are prone to errors arising from inaccuracies in these coordinates or differences in the relative orientations of domains between molecules. In this p...

The neuropharmacological effect of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the rhizome of Drynaria quercifolia J. Smith were studied in mice by intraperitoneal administration. The tests used were determination of effect on duration of diazepam-induced sleep, determination of effect on nikethamide-induced toxicity, light-dark test and force swimming test. The du...

By recurring to Geometric Probability methods it is shown that the coupling constants, αEM , αW , αC , associated with the electromagnetic, weak and strong (color) force are given by the ratios of measures of the sphere S and the Shilov boundaries Q3 =S 2 ×RP , squashed S, respectively, with respect to the Wyler measure ΩWyler[Q4] of the Shilov boundary Q4 =S ×RP 1 of the poly-disc D4 (8 real d...

Variations on DNA sequences profoundly affect how we develop diseases and respond to pathogens and drugs. Atomic force microscopy (AFM) provides a nanomechanical imaging approach for genetic analysis with nanometre resolution. However, unlike fluorescence imaging that has wavelength-specific fluorophores, the lack of shape-specific labels largely hampers widespread applications of AFM imaging. ...