In article number 2100370, Alexandros Marios Sofias, Sjoerd Hak, and co-workers, report that cRGD-decorated lipid nanoparticles target inflammatory lesions via hitchhiking with phagocytes. Through a complementary approach including state-of-the-art intravital microscopy, it is identified neutrophils monocytes take up liposomes nanoemulsions in circulation subsequently home to the lesion. Cover ...

Foot drop is commonly caused by lumbar radiculopathy, peroneal nerve injury, spinal stenosis and other systemic diseases. It is usually thought as peripheral etiology, but it could be attributed to a central lesion, too. However, central lesions are rarely reported. We report a case diagnosed as a left parasagittal parietal tumor, in which drop foot was the only abnormal neurologic finding.

The corticospinal tract is the motor pathway in the human brain, and corona radiata (CR) is an important location to diagnose stroke. We detected hand and foot motor fiber tracts in the CR to investigate accurate locations using diffusion-tensor imaging (DTI) and functional imaging. Ten right-handed normal volunteers participated in this study. We used a probabilistic tracking algorithm, a brai...

Diabetes mellitus is one of the most common metabolic diseases. More than 154 million people are estimated to have diabetes worldwide. The prevalence of diabetes among veterans has increased to 17%, more than double the prevalence in the general population. Diabetic foot ulcers are a frequent late complication in diabetic patients and the most prevalent lesion of the diabetic foot. Foot examina...

The hand-foot syndrome (HFS) is an erythematous skin lesion of the palma and planta of the hand and feet is most often caused by cytostatic chemotherapy. The impact on the patients' quality of life depends on the extent of the disease. The pathogenesis of the hand-foot syndrome has not yet been sufficiently clarified and it can only be treated symptomatically. We performed an extensive literatu...

Rehabilitation following spinal cord injury is likely to depend on recovery of corticospinal systems. Here we investigate whether transmission in the corticospinal tract may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 15 healthy controls. Coherence in the 10- to 20-Hz...

32 33 Rehabilitation following spinal cord injury is likely to depend on recovery of 34 corticospinal systems. Here we investigate whether transmission in the corticospinal tract 35 may explain foot drop (inability to dorsiflex ankle) in persons with spinal cord lesion. 36 The study was performed in 24 persons with incomplete spinal cord lesion (C1 to L1) and 37 15 healthy controls. Coherence i...

Diabetic foot ulcers should be treated to maintain health status, improve quality of life, reduce the number of amputations and lower costs. Many centres that treat diabetic foot ulcers use a multidisciplinary team approach, which comprises medical staff, nurses, podiatrists and an orthotist. At the Manchester Diabetes Centre, larval therapy has been used for several years to debride sloughy di...

Benign Giant Cell Tumor is a relatively common benign lesion which usually appears as an enlarging painless mass and has a synovial origin. Although benign giant cell tumors generally involve tendon sheaths, they are infrequently documented in the foot. A 45 years old female presented with a complaint of a lump on the top of her left foot. Under general anesthesia with a pneumatic tourtniquet t...

Injury to the sciatic nerve is one of the more serious complications of acetabular fracture and traumatic dislocation of the hip, both in the short and long term. We have reviewed prospectively patients, treated in our unit, for acetabular fractures who had concomitant injury to the sciatic nerve, with the aim of predicting the functional outcome after these injuries. Of 136 patients who underw...