background: leber hereditary optic neuropathy (lhon) is an inherited form of bilateral optic atrophy leading to the loss of central vision.  the primary cause of vision loss is mutation in the mitochondrial dna (mtdna), however, unknown secon­dary genetic and/or epigenetic risk factors are suggested to influence its neuropathology.  in this study folate gene polymor­phisms were examined as a po...

Folic acid plays a basic role in fetal growth, development and prevents fetalmalformations. Pregnant woman's perception regarding folic supplementation is critical

background: spina bifida and anencephaly are among serious and fatal anomalies in infants that may lead to a 50-70% of reduction in incidence when folic acid is consumed before conception. methods: in a cross sectional study, 2997 pregnant women were evaluated to determine the level of their knowledge and practice about using folic acid in fars province, southern iran. results: eighty percent o...

In this work, the structural and electronic properties of folic acid molecule on functionalized (7,0)zigzag single-walled carbon nanotube was studied in gas phase on the basis of density functionaltheory (DFT). Furthermore, covalent interaction of folic acid with single-walled carbon nanotube wasinvestigated and its quantum molecular descriptors and binding energies were calculated. The DFTB3LY...

objective(s)previous studies have shown that vitamin b as well as folate supplementation has been implicated in cognitive and neurodegenerative disorders including alzheimer’s and parkinson's diseases. the aim of present study was to evaluate the effects of folic acid on passive avoidance task and motor coordination in healthy adult male rats.materials and methodsanimals were randomly divi...

BACKGROUND: In ovo injection of nutrients as an early feeding method in birds directly supplies the nu- trients to the developing embryo. OBJECTIVES: This study was designed to evaluate the effects of in ovo injection of nicotonic acid, panto- thenic acid and folic acid on the performance and immune system of broilers. METHODS: </st...

The Food and Drug Administration mandated that by 1998, all enriched cereal grain products (ECGP) be fortified with folic acid in order to prevent the occurrence of neural tube defects. The Institute of Medicine established the tolerable upper intake level (UL) for folic acid (1000 µg/day for adults) in 1998. We characterized U.S. adults with usual daily folic acid intake exceeding the UL. Usin...

Hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. The present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on pH-sensitive polymers such as poly (acrylic acid). Poly (acrylic acid), p(AA), hydrogel has been synthesized by radical po...