نتایج جستجو برای: folding mechanism
تعداد نتایج: 590973 فیلتر نتایج به سال:
در این پایان نامه، با بهره گیری از ویژگی های ترانزیستورset، ساختار جدیدی برای مبدل آنالوگ به دیجیتال مبتنی بر ساختار folding ارائه می شود و با مقایسه بین ساختار پیشنهادی و ساختارهای پیشین مشاهده می شود که فرکانس نمونه برداری بهبود یافته و از طرف دیگر تلفات توانی و تعداد اجزا به کار گرفته شده در ساختار کاهش چشم گیری داشته است. البته با به کار گیری مدار ترکیبی set/cmos در ساختار پیشنهادی شاهد بهت...
Intrinsically disordered proteins often become structured upon interacting with their partners. The mechanism of this 'folding upon binding' process, however, has not been fully characterised yet. Here we present a study of the folding of the intrinsically disordered transactivation domain of c-Myb (c-Myb) upon binding its partner KIX. By determining the structure of the folding transition stat...
That protein folding is a non-random, guided process has been known even prior to Levinthal's paradox; yet, guided searches, attendant mechanisms and their relation to primary sequence remain obscure. Using extensive molecular dynamics simulations of a β-hairpin with key sequence features similar to those of >13,000 β-hairpins in full proteins, we provide significant insights on the entire pre-...
There are many unresolved questions regarding the role of water in protein folding. Does water merely induce hydrophobic forces, or does the discrete nature of water play a structural role in folding? Are the nonadditive aspects of water important in determining the folding mechanism? To help to address these questions, we have performed simulations of the folding of a model protein (BBA5) in e...
Circular permutation is a common molecular mechanism for evolution of proteins. However, such re-arrangement of secondary structure connectivity may interfere with the folding mechanism causing accumulation of folding intermediates, which in turn can lead to misfolding. We solved the crystal structure and investigated the folding pathway of a circularly permuted variant of a PDZ domain, SAP97 P...
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