G-quadruplex là cấu trúc bậc 2 của DNA hay RNA mà đóng vai trò quan trọng trong các quá trình sinh học như sao chép, phiên mã, dịch mã và kéo dài telomeres. Do đó, được xem một phân tử mục tiêu việc thiết kế thuốc trúng đích ứng dụng y sinh. Trong nghiên cứu này, nuclease mới phát triển có khả năng nhắm song thực hiện chức cắt tại vị trí đặc hiệu. Enzyme tạo ra bằng phương pháp kết hợp peptit R...

Callipyge (CLPG) is a candidate gene with significant effect on meat quality and growth in sheep. The aim of this study was to investigate the polymorphism CLPG Akkaraman breed. In study, DNAs obtained from blood samples 50 sheep used as material. CLPG/Faq1 examined all individuals using method PCR-RFLP. Only A allele AA genotype were detected after PCR-RFLP procedure. This first which investig...

Ovarian cancer causes more deaths than any other cancer of the female reproductive system. The vitamin D receptor (VDR) is weakly to moderately expressed in normal ovarian cell, but is more strongly expressed in ovarian cancer line and tumor tissue. In vitro studies have reported that vitamin D administration inhibits cell growth and induces apoptosis in a dose dependent manner in both animal a...

There is a lot of debate on the relationship between vitamin D receptor polymorphisms and risk of breast cancer. Herein, we quantitatively analyzed the published case-control studies on this relationship by meta- analysis, performing a bibliographic search from Pubmed and CNKI up to July 31, 2013. The included case- control studies for Fok1, Bsm1, Taq1, Apa1, Cdx2 and Poly-A were 16, 19, 20, 10...

BACKGROUND AND OBJECTIVE The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. PATIENTS AND METHODS This cross-sectional case control study was performed between March 20...

Rudgers and Sastry-Dent Approaches to improving agricultural crops have relied on either mutational or traditional breeding and selection methods or through the random introduction of novel genes into crops by transformation (e.g. using Agrobacterium). These approaches are inherently time-consuming, inefficient and expensive, especially for developing complex, multi-trait products that are now ...