Ovarian cancer causes more deaths than any other cancer of the female reproductive system. The vitamin D receptor (VDR) is weakly to moderately expressed in normal ovarian cell, but is more strongly expressed in ovarian cancer line and tumor tissue. In vitro studies have reported that vitamin D administration inhibits cell growth and induces apoptosis in a dose dependent manner in both animal a...

There is a lot of debate on the relationship between vitamin D receptor polymorphisms and risk of breast cancer. Herein, we quantitatively analyzed the published case-control studies on this relationship by meta- analysis, performing a bibliographic search from Pubmed and CNKI up to July 31, 2013. The included case- control studies for Fok1, Bsm1, Taq1, Apa1, Cdx2 and Poly-A were 16, 19, 20, 10...

BACKGROUND Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among African-Americans and Hispanics. This study examines whether VDR gene polymorphisms are associated with breast cancer in these cohorts. MET...

BACKGROUND & OBJECTIVES The Vitamin-D receptor (VDR) regulates vitamin D levels and calcium metabolism in the body and these are known to be associated with endocrine dysfunctions, insulin resistance and type-2 diabetes in polycystic ovarian syndrome (PCOS). Studies on VDR polymorphisms among PCOS women are sparse. We undertook this study to investigate the association pattern of VDR polymorphi...

BACKGROUND AND OBJECTIVE The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. PATIENTS AND METHODS This cross-sectional case control study was performed between March 20...

Rudgers and Sastry-Dent Approaches to improving agricultural crops have relied on either mutational or traditional breeding and selection methods or through the random introduction of novel genes into crops by transformation (e.g. using Agrobacterium). These approaches are inherently time-consuming, inefficient and expensive, especially for developing complex, multi-trait products that are now ...

BACKGROUND The exact etiology of recurrent tonsillopharyngitis in children is not clear. Recurrent tonsillitis in children has multifactorial etiology like most of the diseases in childhood. In this study, our aim was to determine the potential role of vitamin D in recurrent tonsillitis by measuring serum 25-OH vitamin D levels and determining the vitamin D receptor polymorphism among children ...