A novel method for the simultaneous high-performance liquid chromatographic determination of nortriptyline hydrochloride and fluphenazine hydrochloride was developed and validated. Fluvastatin sodium was used as internal standard. The determination was performed on a Hypersil Gold C8 column (250 mm × 4.6 mm i.d., 5 μm particle size) at 25 °C; the mobile phase, consisting of a mixture of formic ...

BACKGROUND Toxoplasma gondii is the most common parasite causing latent cerebral infections in human. It has been shown that some anti-psychotic drugs are able to inhibit the proliferation of the parasite in in vitro study. There is very limited data regarding the inhibitory effect of anti-psychotics on Toxoplasma in in vivo. In this study, we evaluated anti-Toxoplasma activity of fluphenazine ...

The effect of a number of neuroleptics and tricyclic antidepressants on the activity of rat hypothalamic tyrosine hydroxylase was studied utilizing a direct spectrophotometric method. All the neuroleptics (but not the antidepressants) were able to reverse the substrate inhibition of the enzyme occurring when the tyrosine concentration in the medium was increased. Haloperidol, haloanisone and fl...

Introduction of chlorpromazine by Delay and Danikcr in 1952 revolutionized the treatment of acute schizophrenia. However, chronic form of the illness still remains a challenge, mainly because of noncompliance of the patients with the therapeutic regimen (Diamond and Marks, 1960; Olson and Peterson, 1960; Hare and Willcox, 1967 ; Wilson and Enoch, 1967 and Ayd, 1975). Another factor is the errat...