an oral sustained-release floating tablet formulation of metformin hcl was designed and developed. effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc-peo polymer combination, respectively. tablet composition was optimized by response surface methodology (rsm). seventeen (17) trial formulations were analyzed according to box-behnken desi...

Molecular dynamics simulations of Helium (He), Neon (Ne), Argon (Ar), Krpton (Kr) and Xenon (Xe) encapsulated in C60 are discussed, as well simulations of Fullerenes containing anywhere from two to four He atoms. Even for single atom encapsulates, no species resides at the geometric center of the Fullerene cage. Smaller atoms sit more off-center than larger ones, and He appears to be a special ...

Abstract We provide a practical demonstration that it is possible to systematically generate variety of high-performance micro-kernels for the general matrix multiplication ( gemm ) via generic templates which can be easily customized different processor architectures and micro-kernel dimensions. These employ vector intrinsics exploit SIMD (single instruction, multiple data) units in current ge...

As people further develop space with advanced technology, robots have played a significant role in on-orbit servicing missions. Space can carry out more risky and complicated missions less cost than astronauts. Dual-arm perform complex effectively single-arm robots. Since the coupled dynamics between free-floating base arms exist robots, accurate coordinate control of is essential. Spacecraft r...

A Modular Multilevel Converter (MMC) is an attractive solution for power conversion without transformers. As MMC consists of cascade connections and floating dc capacitors, it requires continuous voltage monitoring. An adaptive observer design has been presented to estimate the capacitor voltages from the measurement of arm currents. This work introduces a capacitance value of the cell capacito...

ultimate limits of an open pit, which define its size and shape at the end of the mine’s life, is the pit with the highest profit value. a number of algorithms such as floating or moving cone method, floating cone method ii and the corrected forms of this method, the korobov algorithm and the corrected form of this method, dynamic programming and the lerchs and grossmann algorithm based on grap...

The elevated plus-maze is an apparatus composed of enclosed and open (elevated) arms and time spent in the open arms by a rat can be increased/decreased by anxiolytic/anxiogenic agents. In the forced swim test, floating behavior is used as an index of behavioral despair and can be decreased by antidepressant agents. As the comorbidity between anxiety and depression is a remarkable issue in huma...