We describe a Markov state model for a cloned potassium channel of the human heart ( 1 KvLQT I ). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the “SPSA” optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the act...

The energy variance optimization algorithm over a fixed ensemble of configurations in variational Monte Carlo often encounters problems of convergence. Being formally identical to a problem of fitting data, we re-examine it from a statistical maximum-likelihood point of view. We show that the assumption of an underlying Gaussian distribution of the local energy, implicit in the standard varianc...

BACKGROUND Hearing impairment is the most common body system disability in veterans. In 2008, nearly 520,000 veterans had a disability for hearing loss through the Department of Veterans Affairs (VA). Changes in eligibility for hearing aid services, along with the aging population, contributed to a greater than 300% increase in the number of hearing aids dispensed from 1996 to 2006. In 2006, th...

this work is a continuation of [a‎. ‎o‎. ‎asar‎, ‎‎‎on infinitely generated groups whose proper subgroups are solvable‎, ‎{em j‎. ‎algebra}‎, ‎{bf 399} (2014) 870-886.]‎, ‎where it was shown‎ ‎that a perfect infinitely generated group whose proper subgroups‎ are solvable and in whose homomorphic images normal closures of ‎finitely generated subgroups are residually nilpotent is a fitting‎‎$p$-g...

OBJECTIVE To assess the short-term acceptability, aspects of use and user satisfaction with the Oves cap. DESIGN, SETTING AND SUBJECTS A multicentre observational study, commissioned by Veos Ltd, manufacturers of the Oves cap, was carried out by the UK Family Planning and Reproductive Health Research Network in collaboration with the Institute of Population Studies, University of Exeter, Exet...