Hiltrud Brauch and Werner Schroth, Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart; and University Tübingen, Tübingen, Germany Matthew P. Goetz, Mayo Clinic, Rochester, MN Thomas E. Mürdter and Stefan Winter, Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart; and University Tübingen, Tübingen, Germany James N. Ingle, Mayo Clinic, Rochester, MN Mat...

Innate airway hyperresponsiveness (AHR) is well modeled by two strains of rat, the hyperresponsive Fischer 344 rat and the normoresponsive Lewis rat. Arginase has been implicated in AHR associated with allergic asthma models. We addressed the role of arginase in innate AHR using the Fischer-Lewis model. In vivo arginase inhibition with N(ω)-hydroxy-nor-arginine (nor-NOHA) was evaluated on metha...

Editorial Board Members Kent Bach, San Francisco State University Michael Bratman. Stanford University Nancy Cartwright. London School of Economics Richard Feldman. University of Rochester Martin Fischer, University of California, Riverside F. Gler, University of Idaho Ivanhoe, University of Michigan McKinsey, Wayne John Perry. Stanford University James Rachels. University ofAlabama at Birmingh...

The presence of phenylethylamine (PEA) in human urine was demonstrated by several investigators (Jepson et al., 1960; Perry, 1962; Oates et al., 1963; Fischer et al., 1968; Boulton and Mil-ward, 1971; Fischer et al., 1972; Mosnaim and Inwang, 1973; Schweitzer et al., 1975). Further, a decrease of PEA was reported in the urine of depressed patients (Fischer et al., 1972; Rodriguez Casanova and F...

Histocompatible Fischer 344 and Lewis rats have been shown to differ on a wide variety of behavioral, chemical, and molecular measures. This investigation aimed to clarify strain differences in unconditioned motor behavior with respect to the amount and patterns of movements. Twenty female Fischer 344, Lewis, and Sprague-Dawley were tested in the Behavioral Pattern Monitor for 30 min. The locom...