A baby girl referred from the newborn unit at day 1 of life with a pedunculated soft tissue 3x3.5x 3 cm mass located pre-axially on the palm at the base of her pollex finger. (Fig. 1) The rest of the local and systemic examination was normal. Ultrasonography of the abdomen did not reveal any other congenital anomaly. The lesion was excised. Histopathological examination reported the lesion to b...

Giant lipoma of the hand is rare. The diagnosis is based on a clinical tumor and acroparesthesia from compression of the median and ulnar nerves. The MRI is the best exam to study local extension. Fibrolipoma of the median nerve and low-grade liposarcoma are the principal differential diagnoses.