OBJECTIVE Fibroblast Growth Factor 21 (FGF21) is a potent stimulator of brown fat thermogenesis that improves insulin sensitivity, ameliorates hepatosteatosis, and induces weight loss by engaging the receptor complex comprised of Fibroblast Growth Factor Receptor 1 (FGFR1) and the requisite coreceptor βKlotho. Previously, recombinant antibody proteins that activate the FGFR1/βKlotho complex wer...

Fibroblast growth factor receptor 1 (Fgfr1) is expressed at high levels by progenitor cells of the ventricular zone (VZ) within the hippocampal primordium. To investigate the role of Fgfr1 in these cells, in vivo Cre recombination of "floxed" Fgfr1 alleles was directed to cells of the radial glial lineage by using the human glial fibrillary acidic protein promoter. Radial glial-like cells of th...

preeclampsia is an important pregnancy disorder with serious maternal and fetal complications which its etiology has not been completely understood yet. early diagnosis and management of disease could reduce its potential side effects. the vascular endothelial growth factor (vegf) family including vegf-a is the most potent endothelial growth factor which induces angiogenesis and endothelial cel...

Cell number is an important determinant of adipose tissue mass, and the coordinated proliferation and differentiation of preadipocytes into mature lipid-laden adipocytes underpins the increased adipose tissue mass associated with obesity. Despite this, the molecular cues governing such adipose tissue expansion are poorly understood. We previously reported that fibroblast growth factor-1 (FGF-1)...

RATIONALE Prostaglandin (PG)E(2) exerts temporally distinct actions on blood vessels, immediate vasodilatation, and long-term activation of angiogenesis. OBJECTIVE To study the mechanism of PGE(2) induction of angiogenesis, we characterized its effect on fibroblast growth factor (FGF)-2 signaling in cultured endothelial cells and in ex vivo and in vivo assays of blood vessel formation. METH...

Recently, research into the development of new targeted therapies has focused on specific genetic alterations to create advanced, more personalized treatment. One of the target genes, fibroblast growth factor receptor-1 (FGFR1), has been reported to be amplified in estrogen receptor (ER)-positive subtype breast cancer, and is considered one possible mechanism of endocrine resistance through cro...

previous studies have demonstrated that vascular endothelial growth factor (vegf) can trigger angiogenesis as well as inflammation through binding to its membranous receptor-1 on endothelial and inflammatory cells. we aimed to correlate the circulatory number of cells expressing such receptor as well as the serum level of vegf and the soluble form of its receptor-1 (svegfr1) to the severity of ...

PURPOSE Fibroblast growth factor receptor 1 (FGFR1) and FGFR2 amplifications are observed in approximately 10% of breast cancers and are related to poor outcomes. We evaluated whether dovitinib (TKI258), an inhibitor of FGFR1, FGFR2, and FGFR3, presented antitumor activity in FGFR-amplified breast cancers. EXPERIMENTAL DESIGN Preclinical activity of dovitinib was evaluated in both breast canc...

Intercellular communication is needed for both the generation of the mesodermal germ layer and its division into distinct subpopulations. To dissect the functions of fibroblast growth factor receptor-1 (FGFR1) during mouse gastrulation as well as to gain insights into its possible roles during later embryonic development, we have introduced specific mutations into the Fgfr1 locus by gene target...

streszczenie Zespół Pfeiffera (OMIM#101600) jest rzadkim zespołem uwarunkowanym genetycznie zaliczanym do dysostoz czaszkowo-twarzowych, który dziedziczy się w sposób autosomalnie dominujący ze zmienną ekspresją cech klinicznych. Występuje z częstością około 1:100 000 wśród żywo urodzonych dzieci. Typowe objawy zespołu obejmują: przedwczesne zarastanie szwów czaszkowych (kraniosynostoza), hipop...