geometry. !& 1993 Academic Press, lnc. ing and inflammation, then a rational basis for the design and application ofpharmacologic modulators of cell behavior to augment or mitigate wound contraction (as appropriate for the nature of the wound being managed) would be available. The model proposed here is a first attempt in that direction. A preponderance of evidence implicates fibroblastic cells...

Pelvic organ prolapse (POP) remains a great therapeutic challenge with no optimal treatment available. Tissue maintenance and remodelling are performed by fibroblasts, therefore altered cellular functionality may influence tissue quality. In this study, we evaluated functional characteristics of fibroblastic cells from tissues involved in POP. To rule out normal ageing tissue degeneration, biop...

A naturally occurring cutaneous fibroma of deer has proven to be experimentally transmissible in deer. The causative agent is a virus that is readily alterable through Berkefeld N candles and that survives in fibroma tissue for at least as long as 27 months in glycerol-saline at -20 degrees C. The experimentally produced deer fibroma has an incubation period of about 7 weeks, a very slow rate o...

Objective(S): The chitosan - Fe3O4 core - shell nanoparticles were synthesized. The nanoparticles should be coated properly in the shape of core-shell, so that they remain hidden from the body's immune system after coating. Effects of different molecular weight in coating were investigated. Methods: Nanoparticles coated with low and ...

Postnatal tissue-specific stem/progenitor cells hold great promise to enhance repair of damaged tissues. Many of these cells are retrieved from bone marrow or adipose tissue via invasive procedures. Peripheral blood is an ideal alternative source for the stem/progenitor cells because of its ease of retrieval. We present a coculture system that routinely produces a group of cells from adult peri...

Zinc-fluoride glass nanoparticles (Zinc-F) release several ions, such as fluoride, zinc and calcium through acid-base reactions. The aim of this study was to evaluate the antibacterial cytotoxic properties Zinc-F. Antibacterial tests showed that a Zinc-F eluting solution significantly reduced turbidity colony-forming units Streptococcus mutans Actinomyces naeslundii, compared calcium-fluoroalum...

MDCK cells expressing RhoA or Rac1 mutants under control of the tetracycline repressible transactivator were used to examine short-term effects of known amounts of each mutant before, during, or after development of cell polarity. At low cell density, Rac1V12 cells had a flattened morphology and intact cell-cell contacts, whereas Rac1N17 cells were tightly compacted. Abnormal intracellular aggr...