Objective- This study aimed to evaluate the feasibility of using platelet rich fibrin membrane as a novel on-lay patching biomaterial in canine esophagotomy and its effects on esophageal wound healing. Design- Experimental study. Animals- Eight adult mixed breed dogs of both sexes equally allocated to control and treatment groups.<b...

The present study was designed to evaluate the effects of platelet growth factors and periosteal mesenchymal stem cells on bone healing process, radiographically. Forty male White New Zealand rabbits in five equal groups were used in this study. A 2 mm full thickness bone defect was made in left radial bone of each animal. In group A (control) the defect was left with no medical intervention. I...

objective: acute mesenteric ischemia (ima) is a vascular emergency with broad variability of clinical presentations and non-specific laboratory findings. therefore, there is a significant need for reliable serological markers of ischemia. various laboratory studies may be performed for suspected ami, but in general, such studies will not establish the diagnosis. methods: in a prospective, non-i...

Biomaterial Fibrin Clot Structures Stylized fibrin clots are presented in article number 2100988 by Anna Waterhouse and co-workers. Less dense on hydrophobic (right) compared to hydrophilic (left) polystyrene more easily lysed, demonstrating potential for targeted fibrinolytic treatment improved hemocompatible device design.

Background: In recent years, transplantation of cryopreserved ovarian tissue has proved to be a promising approach to restore fertility in cancer patients. However, such a procedure cannot be carried out in women at risk of ovarian involvement due to the threat of reintroducing malignant cells. The aim of this study was therefore to create an artificial ovary as an alternative to restore fertil...

Abnormal fibrin architecture is thought to be a determinant factor of hypofibrinolysis. However, because of the lack of structural knowledge of the process of fibrin digestion, relationships between fibrin architecture and hypofibrinolysis remain controversial. To elucidate further structural and dynamic changes occurring during fibrinolysis, cross-linked plasma fibrin was labeled with colloida...

Thrombus fragmentation during endovascular stroke treatment, such as mechanical thrombectomy, leads to downstream emboli, resulting in poor clinical outcomes. Clinical studies suggest that risk is dependent on clot composition. This current study presents the first experimental characterization of composition-dependent fracture properties blood clots, addition development a predictive model for...

The fibrin polymers formed in solution during the earliest phase of the fibrinogen-fibrin conversion are shown to be stable soluble molecules at pH7.4 and 0.15m- or 0.3m-NaCl. The various sequential soluble fibrin polymers produced from the fibrinogen-thrombin reaction can be observed by gel chromatography and can be isolated for characterization. The mechanism of fibrin polymerization proposed...